The pancreatic lipase inhibitory activity of the rhizome of Alpinia officinarum (AO) and its antihyperlipidemic activity were measured. When the water extract of AO was fractionated stepwise with organic solvents, the ethyl acetate fraction exhibited the most potent inhibition. 3-Methylethergalangin was isolated from that fraction as an inhibitor of pancreatic lipase with an IC(50) value of 1.3...

When desialylated ceruloplasmin (ASCPN), labeled with 64Cu and with 3H in its galactose residues, is injected intravenously into a rat, more than half of the radioactivity can be recovered within minutes in ASCPN precipitated immunochemically from liver homogenates. Both radioautographic studies and measurements of hepatic uptake of ASCPN following blockade of the reticuloendothelial system ind...

There are two ways to introduce the notion of frequency response for sampled-data systems. One is based on the so-called lifting, and the other based on an interpretation of steady-state response in terms of impulse modulation. This paper proves the equivalence of these two notions; in particular, it establishes a more direct link of the second approach to the H” norm, and also provides the fir...

Five novel derivatives of N-(9,10-dihydro-9,10-dioxoanthracenyl)-1H-indole-2-carboxamide were synthesized and their lipid-lowering effects studied in hyperlipidemic rats. Fusion of the anthraquinone derivatives at high temperature with 5-indole-2-carbonyl chloride, followed by recrystallization from chloroform/methanol gave the desired compounds in excellent yields. Compounds 1 to 5 at a non-to...

screening for lung cancer in asbestos occupational exposure: a systematic review and meta-analysis. Chest 2014;145:1339-1346. 14. Tammemägi MC, Katki HA, Hocking WG, Church TR, Caporaso N, Kvale PA, Chaturvedi AK, Silvestri GA, Riley TL, Commins J, et al. Selection criteria for lung-cancer screening. N Engl J Med 2013;368: 728–736. 15. Field JK, Oudkerk M, Pedersen JH, Duffy SW. Prospects for p...

We analyzed the molecular mutations of eight known Japanese glucose-6-phosphate dehydrogenase (G6PD) variants with unique biochemical properties. Three of them were caused by novel missense mutations: G6PD Musashino by 185 C-->T, G6PD Asahikawa by 695 G-->A, and G6PD Kamiube by 1387 C-->T. Predicted amino acid substitutions causing asymptomatic variants G6PD Musashino (62 Pro-->Phe) and G6PD Ka...

High blood cholesterol levels are consistently associated with higher risk of coronary heart disease, and other life-threatening cardiovascular and cerebro-vascular damage, including fatal strokes. In the present study methanolic extract of Annona cherimola was evaluated for its antihyperlipidemic potential. Acute hyperlipidemia was induced by single administration of Triton WR 1339 (Tyloxapol)...

Rabbits subjected to subtotal hepatectomy failed to develop increased serum cholesterol levels following parenteral injection of triton WR 1339, the finding indicating that the liver is essential for the establishment of the hypercholesterolemia induced by surface-active agents. The cholesterol content of the livers of rabbits rendered hyperlipemic by means of triton remained unchanged both dur...

On the basis of the previous mapping study for male sterility gene Bnms3, we further narrowed it from a genomic region of 470kb to 93.7kb, using a large population consisting of 1339 fertile and 1151 sterile plants, and locus specific markers derived from Brassica rapa of A10. Seventeen open reading frames (ORFs) were predicated in the target region. Of them, two most likely candidate genes wer...

N Engl J Med 2006;355:1339-44. Copyright © 2006 Massachusetts Medical Society. Medical education seems to be in a perpetual state of unrest. From the early 1900s to the present, more than a score of reports from foundations, educational bodies, and professional task forces have criticized medical education for emphasizing scientific knowledge over biologic understanding, clinical reasoning, pra...