نتایج جستجو برای: 1382

تعداد نتایج: 4994  

2008
James G. Elkins Mircea Podar David E. Graham Kira S. Makarova Yuri Wolf Lennart Randau Brian P. Hedlund Céline Brochier-Armanet Victor Kunin Iain Anderson Alla Lapidus Eugene Goltsman Kerrie Barry Eugene V. Koonin Phil Hugenholtz Nikos Kyrpides Gerhard Wanner Paul Richardson Martin Keller Karl O. Stetter

The candidate division Korarchaeota comprises a group of uncultivated microorganisms which, by their small subunit rRNA phylogeny, may have diverged early from the major archaeal phyla Crenarchaeota and Euryarchaeota. Here we report the initial characterization of a member of the Korarchaeota with the proposed name, “Candidatus Korarchaeum cryptofilum” which exhibits an ultra-thin, filamentous ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1985
J R Lackner B Shenker

We evaluated the influence of proprioceptive information about arm position on the perceptual localization of auditory and visual targets attached to the hand. Our approach was to distort the perceived position of the restrained arm by means of mechanical vibration of the biceps brachii muscle; such vibration elicits compelling apparent extension of the stationary forearm (Goodwin, G. M., D. I....

2003
WILLIAM C. ALBERT JOSEPH S. HANDLER

ALBERT, ~VILLIAM C., AND JOSEPH S. HANDLER. EJect of PGEl, indomethacin, and fo&hloretin phosphate on toad bladder response to ADH Am. J. Physiol, 226(6) : 1382-l 386. 1974.-Exogenous PGEr inhibits the short-circuit current response, as well as the water permeability response of the toad bladder to vasopressin. Since PGEI does not inhibit either response to cyclic AMP, it is thought to act by i...

2001
M. Ruiz - Ortega O. Lorenzo M. Rupérez V. Esteban Y. Suzuki S. Mezzano J. J. Plaza J. Egido

The renin-angiotensin system (RAS) has emerged as one of the essential links in the pathophysiology of vascular disease. Angiotensin (Ang) II, the main peptide of the RAS, was considered as a vasoactive hormone, but in the past years, this view has been modified to a growth factor that regulates cell proliferation/apoptosis and fibrosis. Recently, this view has been enlarged with a novel concep...

2011
SHAHLA BAHREMAND M.D A. ZAMANI

Background: Triple therapy with a proton pump inhibitor, c1arithromycin and amoxicillin and quadruple therapy with a proton pump inhibitor, bismuth citrate, met­ ronidazole and amoxicillin have been proposed in Maastricht 2000 as the optimal treat­ ment of Helicobacter pylori infection. We aimed to compare these two regimens in Iranian pediatric patients. Methods: A randomized clinical trial in...

2013
Paul C. Churchill Monique C. Churchill Anil K. Bidani Karen A. Griffin Maria Picken Michal Pravenec Vladmir Kren Jia-Ming Wang Ning Wang Theodore W. Kurtz

To test the hypothesis that genetic factors can determine susceptibility to hypertension-induced renal damage, we derived an experimental animal model in which two genetically different yet histocompatible kidneys are chronically and simultaneously exposed to the same blood pressure profile and metabolic environment within the same host. Kidneys from normotensive Brown Norway rats were transpla...

2014
Matthew Hutzler Matthew A. Cerny Young-Sun Yang Constance Asher Diane Wong Kyle Gilpin

BIBX1382 was an epidermal growth factor receptor inhibitor under clinical investigation for treatment of cancer. This candidate possessed an attractive preclinical absorption, distribution, metabolism, and excretion profile, yet failed in clinical studies due in part to poor oral exposure, resulting from extensive metabolism by aldehyde oxidase (AO). In vitro metabolism studies were performed i...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2014
J Matthew Hutzler Matthew A Cerny Young-Sun Yang Constance Asher Diane Wong Kosea Frederick Kyle Gilpin

BIBX1382 was an epidermal growth factor receptor inhibitor under clinical investigation for treatment of cancer. This candidate possessed an attractive preclinical absorption, distribution, metabolism, and excretion profile, yet failed in clinical studies due in part to poor oral exposure, resulting from extensive metabolism by aldehyde oxidase (AO). In vitro metabolism studies were performed i...

ژورنال: زیست شناسی دریا 2012
بهروزخوش قلب, محمدرضا , بهمنی , محمود , توکلی , محمود ,

ارزیابی ذخایر ماهیان خاویاری در حوزه جنوبی دریای خزر (آب های ایران) با هدف تعیین ترکیب گونه‏ای، فراوانی نسبی، فراوانی مطلق و میزان توده زنده گونه‏های مختلف تاس ماهیان انجام گرفت. در این مطالعه، 90 ایستگاه براساس طرح طبقه بندی تصادفی انتخاب و از روش مساحت جاروب شده برای برآورد ذخایر استفاده شد. در اعماق کم تر از 10 متر از ترال 9 متری و برای مناطق با عمق بیش تر از 10 متر از ترال 7/24 متری استفاده...

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