This lecture deals with one of the fundamental issues encountered when constructing a system made up of independent communicating processes: dealing with time and making sure that processes do the right thing at the right time. In essence this comes down to allowing processes to synchronise and coordinate their actions. Coordination refers to coordinating the actions of separate processes relat...

A distributed system is composed of a number of elements, the most important of which are software components, processing nodes and networks. Some of these elements can be specified as part of a distributed system’s design, while others are given (i.e., they have to be accepted as they are). Typically when building a distributed system, the software is under the designer’s control. Depending on...

In the Western world, over 350,000 deaths and $30 billion in medical costs are attributed annually to stroke. Head and spinal cord trauma cause an estimated 250,000 deaths annually and result in medical costs of $15 billion. Although stroke and head/spinal cord trauma are leading causes of disability and death in humans, no adequate neuroprotective treatment is available. Glutamate antagonists ...

Synchronisation and Coordination (Part 2) Transactions A transaction can be regarded as a set of server operations that are guaranteed to appear atomic in the presence of multiple clients and partial failure. The concept of a transaction originates from the database community as a mechanism to maintain the consistency of databases. Transaction management is build around two basic operations: Be...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 1. Essential Physicochemical Properties of Local Anaesthetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 2. Overview of the Toxic Effects of Local Anaesthetics . . . . . . . . . . . . . . . . . ...

2-Methoxyestradiol (2-ME) is an endogenous metabolite of estradiol with promise for cancer chemotherapy, including advanced prostate cancer. We have focused on events related to cell cycle arrest (G1 and G2/M) and induction of apoptosis in human prostate cancer cells. Treatment with 2-ME increased cyclin B1 protein and its associated kinase activity followed by later inhibition of cyclin A-depe...