This paper describes a method of obtaining MOLS of order v = 2np for p a prime power. In particular, it gives 5,7 and 9 MOLS of orders 48,40 and 80 respectively. If x = Min(2p-1 ,2n-1 ,4n-2) , it is conjectured that x MOLS of order v are always-obtainable by this method. Australasian Journ::ll of ~ohmin::ltnrirc: 101 1QQLl \ n .... 17f.;;_1Qg::

Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed ...

Target-guided screening of fragments (TGSOF) was developed and employed in the identification of EV-A71 3C protease (3Cpro) inhibitors. We identified 4-acetylpyridine and 3-acetylpyridine as effective P3 fragments of an inhibitor and obtained the corresponding irreversible inhibitors 12c and 12fvia this method. Furthermore, based on 12c and 12f, we have obtained reversible inhibitors 17c and 17...

Background Chronic mucocutaneous candidiasis (CMC) is a heterogeneous group of primary immunodeficiency diseases (PID) characterized by chronic and recurrent infections of the skin, nails, and oropharynx, mostly caused by Candida sp. CMC is often associated with autoimmune and endocrine disorders. However, CMC may be the only or the main phenotype in patients with AD IL-17F and AR IL-17RA defic...

Psoriasis is a common chronic skin disease characterized by pro-inflammatory environment mediated keratinocytes and both innate adaptative immune responses. This inflammation mostly driven the IL-17/IL-23 axis resulting in production of inflammatory factors (chemokines antimicrobial peptides) keratinocytes. These mediators lead to an amplification loop consequently epidermal hyperplasia. To our...