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Human La protein has been implicated in facilitating internal ribosome entry site (IRES)-mediated translation of hepatitis C virus (HCV). Earlier, we demonstrated that the RNA recognition motif (RRM) encompassing residues 112 to 184 of La protein [La (112-184)] interacts with the HCV IRES near the initiator AUG codon. A synthetic peptide, LaR2C (24-mer), derived from La RRM (112-184), retains R...
Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects. Reduction of miR-184 promotes the expression...
A subtle modification to the Signal-Stability based Adaptive routing protocol along with their performance comparison has been presented in this paper. The modified protocol (MSSA) is found to offer better packet delivery and less link failures.
Local bathymetric, quasi-periodic patterns of oscillation are identified from 26 years of monthly profile surveys taken at two shore-perpendicular transects at Duck, North Carolina, USA. The data cover both the swash and surf zones. Singular Spectrum Analysis (SSA) and Multi-channel Singular Spectrum analysis (MSSA) methods are applied, on the shoreface, to three potential forcings: the monthly...
Introduction: Currently, there is no effective and comprehensive treatment for ischemic stroke. There is strong clinical evidence for the benefits of hypothermia in neuroprotection. Therefore, the present study aimed to determine the effect of mild non-invasive hypothermia by JZL-184 on behavioral improvement in stroke rats. Methods: This study was performed on 5 groups of male mice weighing 2...
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