Autoxidation of para-aminophenol (PAP) has been proposed to account for the selective nephrotoxicity of this compound. However, other studies suggest that hepatic metabolites of PAP rather than the parent compound may be responsible for renal damage. These studies were designed to investigate PAP metabolism in isolated hepatocytes. We synthesized several proposed metabolites for analysis by HPL...

It has been demonstrated by many workers (l-5) that phenols may be conjugated with glucuronic acid or inorganic sulfate in vitro by liver slices and by cell-free preparations. By using a system developed in this laboratory, together with a modification of the analytical procedure described by Levvy and Storey (3), the synthesis of the conjugated sulfate, and possibly of the glucuronide, has bee...

Schiff bases exhibited sensor activity via cyclic voltammetry, colorimetry, and UV-vis study at room temperature. The probes could be employed as a low-cost, ultrasensitive chemo-sensor to detect Cu 2+ Zn in solutions.

The endeavor of this study was to design, synthesize and investigate the in vivo anti-inflammatory and analgesic activity of some novel 2-(2-(benzo[d]oxazol-2-yl) phenylamino)-N-(substituted phenyl) acetamide (2A-2F) derivatives. 2-(2-aminophenyl) benzoxazole (D1) was synthesized by the condensation of anthranilic acid with starting material 2-aminophenol in the existence of poly phosphoric aci...

We describe here the ability of manganese oxide monosheets to aggregate to form layered structures with 4-aminophenol molecules. These aggregated monosheets could be considered as the first step to synthesize a self-assembled layered hybrid of phenol-manganese ions with phenol and manganese(III) and (IV) as exists in the water oxidizing complex of Photosystem II.

Nitrogen-containing ordered mesoporous carbon (NOMC) was synthesized by using m-aminophenol (MAP) as a carbon and nitrogen co-precursor via a co-assembly process with F127 in aqueous phase and exhibited a good catalytic performance for selective oxidation of ethylbenzene.

Using alkaline pH adjustment, the reaction between graphene oxide and L-ascorbic acid led to the formation of a carbocatalyst film with numerous graphene edges protruding out of basal planes, which had a markedly enhanced carbocatalytic activity for conversion of 4-nitrophenol to 4-aminophenol, as compared to that of the carbocatalyst counterpart without involving pH mediation.

Reaction of 1,2-naphthoquinone with primary amines gives a 2-amino-1,4-naphthoquinone derivative which is equivalent to 1,2 to 1,4 carbonyl transposition. For example the reaction of 1,2-naphthoquinone with 4-methoxyaniline gives 2-(4-methoxyanilino)-naphthoquinone-1,4-(4-methoxyanil) (1) and with n-butylamine gives 2-(butylamino)-naphthoquinone-1,4-butylimine (2) respectively. The compounds 1 ...