Carbamoyl anions, generated from N,N-disubstituted formamides and lithium diisopropylamide, add with high diastereoselectivity to chiral N-sulfinyl aldimines and ketimines to provide α-amino amides. The methodology enables the direct introduction of a carbonyl group without the requirement of unmasking steps as with other nucleophiles. The products may be converted to α-amino esters or 1,2-diam...

1. The preparation of a series of compounds derived from diamines by replacing one amino group by a dimethylsulphonium, isothiuronium, trimethylammonium, NN'-dimethylimidazolium or N-methylpyridinium species is described. 2. The behaviour of these compounds as substrates of pig kidney diamine oxidase is reported. All but the trimethylammonium compounds proved to be substrates. 3. Many of these ...

Various N-(5-chloro-6-substituted-benzothiazol-2-yl)-N'-(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from substituted acetophenones. Structures of all the compounds were confirmed on the basis of spectral and elemental analyses. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the sta...

The polyguanamines were prepared by the polymerization of bis[N-(2-anilino-4-chloro-1,3,5-triazine)yl]-4,4’-oxydianiline (Bis(ACT)) with α,ω-alkylene diamines such as 1,12-diaminododecane, 1,10-diaminodecane and 1,8-diaminooctane. NMR analysis Bis(ACT) resulting showed that hydrogen bonds cause between triazine adjacent anilino units. have good solubility in typical organic solvent. Temperature...

The activity of highly purified bovine aortic lysyl oxidase against an insoluble aortic elastin substrate is inhibited by lysine, nonpeptidyl derivatives of lysine, P-aminopropionitrile (BAPN), and aliphatic monoand diamines. Inhibition requires the presence of a primary amino function. Although other stereochemical requirements for inhibition are not unusually rigid, inhibition is sensitive to...

We present herein the catalytic hydrogenation of various urea derivatives to amines and methanol. The reaction is catalyzed by a ruthenium or an iridium Macho pincer complex produces amine methanol in very good excellent yields. Moreover, we also expand this concept demonstrate first example hydrogenative depolymerization polyureas produce diamines moderate

Two different first-principles methods, one based on density functional theory combined with Green’s functions and the other on a configuration interaction method, are used to calculate the electronic transport properties of alkane and silane chains terminated by amine end groups in metal-molecule-metal junctions. The lowvoltage conductance is found to decay exponentially with increasing length...

Alzheimer’s disease (AD) causes dementia and continuous damage to brain cells. Cholinesterase inhibitors can alleviate the condition by increasing communication between nerve cells reducing risk of dementia. In an effort treat disease, we synthesized flurbiprofen-based diamines (1,2 diaminoethane 1,3 diaminopropane) Zn(II), Cu(II) metal complexes characterized them single-crystal X-ray analysis...