Phosphonated isoxazolinyl nucleosides have been prepared via 1,3-dipolar cycloaddition reaction of nitrile oxides with corresponding vinyl or allyl nucleobases for antiviral studies. The cytotoxicity, the anti-HSV activity and the RT-inhibitory activity of the obtained compounds were evaluated and compared with those of AZT and diethyl{(1'SR,4'RS)-1'-[[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1...

Steroid degradation by Comamonas testosteroni and Nocardia restrictus have been intensively studied for the purpose of obtaining materials for steroid drug synthesis. C. testosteroni degrades side chains and converts single/double bonds of certain steroid compounds to produce androsta-1,4-diene 3,17-dione or the derivative. Following 9α-hydroxylation leads to aromatization of the A-ring accompa...

IN THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND (SYSTEMATIC NAME: triethyl-ammonium 2,5-dichloro-4-hy-droxy-3,6-dioxo-cyclo-hexa-1,4-dien-1-olate), C(6)H(16)N(+)·C(6)HCl(2)O(4) (-), two hydrogen chloranilate anions are connected by a pair of bifurcated O-H⋯O hydrogen bonds into a dimeric unit. The triethyl-ammonium cations are linked on both sides of the dimer via bifurcated N-H⋯O hydrogen bonds...

We reported a new naphthalimide fluorescence probe M1[dimethyl 3, 3'-((2-((2-butyl-1, 3-dioxo-2, 3-dihydro-1H-benzo[de] isoquinolin-6-yl) amino) ethyl) azanediyl) dipropionate] with Al3+ system. Its UV-visible absorption spectrum and showed remarkable optical characteristics. The optimal experimental conditions, including reaction temperature, pH, time were investigated. This system possessed g...

4-Oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine (2-thiouracil) is reacted with a series of diazotized aromatic amines to give compounds On the other hand compound is -methylated by methyl iodide giving 4-oxo-2-methylthioxo 1,2,3,4tetrahydropyrimidine which inturn is reacted with a series of diazotized aromatic amines giving arylazo derivatives of the type . In another reaction compound is hydrolyse...

The prostaglandin and leukotriene families of lipid mediators are formed via two distinct biosynthetic pathways that are initiated by the oxygenation of arachidonic acid by either cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LOX), respectively. The 5-LOX product 5S-hydroxyeicosatetraenoic acid, however, can also serve as an efficient substrate for COX-2, forming a bicyclic diendoperoxide with ...

In continuing the search for new analgesics among derivatives of 2,1-benzothiazines, a series of corresponding toluidides and xylidides of 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylic acid has been synthesized by the reaction of ethyl 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylate with equimolar amounts of mono- and dimethyl-substituted anilides in boiling dry xylene. Their...