Multiple hCG-related molecules are present in pregnancy serum and urine samples. These include non-nicked hCG (the hormone), nicked hCG, hyper- and hypoglycosylated hCG, hCG missing the C-terminal extension, free alpha-subunit, large free alpha-subunit, free beta-subunit, nicked free beta-subunit, and beta-core fragment. Over 100 immunoassays are sold for quantifying hCG-related molecules in se...

Previous investigations of patients with gestational trophoblastic neoplasia have shown that their urines often contain carboxyterminal peptide (CTP) fragments of the choriogonadotropin (hCG) beta-subunit as well as forms of hCG deficient in sialic acid. In order to determine whether beta-CTP fragments are among the urinary products of the peripheral degradation of desialylated hCG (as-hCG), us...

Vascular endothelial growth factor (VEGF)-dependent angiogenesis plays a crucial role in corpus luteum formation and its functional maintenance in mammalian ovaries. We recently reported that activation of hypoxia-inducible factor (HIF)-1α signaling contributes to the regulation of VEGF expression in luteal cells (LCs) in response to human chorionic gonadotropin (HCG). We examined whether HIF p...

A procedure is described for testing potential inhibitors of hCG activity in vivo, based on a hormone-responsive alkaline phosphatase in the ovaries of young mice. Standard injections of an antiserum inhibited the response to a subsequent injection of 2 i.u. hCG after an interval of up to 24 h.

UNLABELLED Our aim was to compare Corpus luteum (CL) development and blood plasma concentration of progesterone ([P4]) in thoroughbred mares after spontaneous ( CONTROL C) or human chorionic gonadotrophin (hCG)-induced ovulation. Lactating mares (C=12; hCG=21) were daily teased and mated during second oestrus post-partum. Treated mares received 2500 IU hCG i.v. at first day of behavioural oes...

The ability of women to confirm their pregnancies in the privacy of their own homes was described as a “private little revolution” 35 years ago, when the early version of the modern home pregnancy test, e.p.t (Warner Chilcott), made its debut in the US (1 ). Indeed, pregnancy tests are among the most widely used home diagnostic tests, having accounted for $228 million in sales in 2012 (http://w...

Generation of reactive oxygen species (ROS) is associated with final stages of follicular development and ovulation in mammals. The human chorionic gonadotropin (hCG) mimics the action of luteinizing hormone and triggers follicular development and ovulation. However, it remains unclear whether hCG induces generation of ROS, if yes, whether hCG-mediated increased level of ROS could induce meioti...

Department of Radiation Therapy & Oncology, HCG鄄 Bangalore Institute of Oncology, Bengaluru, Karnataka 560027, India; 2 Department of Radiation Therapy & Oncology, Regional Cancer Center, Indira Gandhi Medical College, Shimla, Himachal Pradesh 171001, India. Swaroop Revannasiddaiah, Department of Radia鄄 tion Therapy & Oncology, HCG鄄 Bangalore Institute of Oncology, Bengalu鄄 ru, Karnataka 560027...

Thirty women undergoing in-vitro fertilization or intracytoplasmic sperm injection considered to be at high risk of ovarian hyperstimulation syndrome (OHSS) were randomly allocated to have early unilateral follicular aspiration (EUFA) (group 1) or coasting (group 2) when the serum oestradiol concentration was >6000 pg/ml and there were more than 15 follicles each of >/=18 mm diameter in each ov...