Background: Parkinson's disease is one of the prevalent degenerative diseases of the neural system. Oxidative stress, which has been recognized as the most important factor of Parkinson's disease, plays a main role in the death of neurons in this disease. Antioxidants have a proved role in the prevention of oxidative stress. Objective: Considering the presence of evidence regarding antioxid...

Clopidogrel, a thienopyridine antiplatelet prodrug, is metabolized by oxidation to 2-oxo-clopidogrel, followed by conversion to its pharmacologically active thiol metabolite. After oral administration of clopidogrel to humans, two thiol isomers (H3 andH4) are observed in plasma,with similar concentrations, and only H4 is active in humans. In this work, themechanism of stereoselectivity in the f...

Thiol esters and boronic acids react to produce ketones under aerobic conditions in the presence of catalytic quantities of a CuI or CuII salt. The reaction occurs at reasonable rates between room temperature and 50 degrees C at neutral pH using thiol esters derived from bulky 2 degrees amides of thiosalicylamides such as those based on N-tert-butyl-2-mercaptobenzamide. In this mechanistically ...

The synthesis of long-arm thiolated beads from beaded polyacrylamide ( $400 mesh, 10-37^ M diameter, 2,000 Dalton inclusion limit) is described. The long spacer arm, polyethylene glycol di(3-mercapto-propionate)(PEG-DMP) was i introduced via thioether formation with haloacetamidoethyl beads. The latter were prepared via the N-hydroxysuccinimide ester (NHS) after surveying a number of peptide co...

Based on plasma-treated single wall carbon nanotubes (SWCNTs), SWCNT/SiO(2) and thiol groups-functionalized SWCNT/SiO(2) hybrids have been fabricated through a sol-gel process. By means of thiol groups, Ag nanoparticles have been in situ synthesized and bonded onto the SiO(2) shell of SWCNT/SiO(2) in the absence of external reducing agent, resulting in the stable carbon nanotube/SiO(2)/Ag nanop...

In this work, we investigated the formation, reactivity, and antiplatelet activity of various mixed disulfide conjugates of clopidogrel. Our results showed that the production of the active metabolite (AM) from 2-oxoclopidogrel by human liver microsomes (HLMs) is greatly affected by the thiol reductants used. Among the 10 thiol compounds tested, glutathione (GSH) is most efficient in producing ...

While thiol-based catalysts are widely employed for chemical protein synthesis relying on peptide thioester chemistry, this is less true selenol-based whose development in its infancy. In study, we compared different selenols derived from the selenocysteamine scaffold their capacity to promote thiol–thioester exchanges water at mildly acidic pH and production of thioesters bis(2-sulfanylethyl)a...