objective(s): alzheimer's disease (ad) is a neurodegenerative disorder in elderly patients. decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. improvement and potentiation of the cholinergic system could be beneficial for treatment of the ad. acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylc...

Nocardia cultures, isolated from soil by use of n-paraffins as the sole carbon source, have been shown to bring about significant oxidation of several methyl-substituted mono- and dicyclic aromatic hydrocarbons. Oxygen uptake by washed cell suspensions was not a reliable indicator of oxidation. Under co-oxidation conditions in shaken flasks, o- and p-xylenes were oxidized to their respective mo...

mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (dmc) is a close structural analog of the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib, that lacks cox-2 inhibitory function. in this study, we aimed to show the apoptotic effects of imatinib in combination with dmc in human ht-29 colorectal cancer (crc)...

The reaction of select copper(II) monocarboxylates Cu(RCOO)2(H2O)x (R = C4H3O, C6H5, H; x 2, 4) with pyrazole (Hpz), carried out in protic solvents, yields mono- or dinuclear species [Cu(RCOO)2(Hpz)n]m (n 4; m 1, 2), always accompanied by tri- hexanuclear derivatives based on the triangular [Cu3(?3-OH)(?-pz)3]2+ fragment. molecular structures all isolated compounds have been established through...

The secretion of the nasal gland from the marsh deer (Odocoileus dichotomus) has shown to be a lipid mixture predominantly containing cholesterol esters, mono- and diester waxes, the latter of which containing 2-hydroxy fatty acids. The alcoholic constituents of the mono- and diester waxes contain considerable amounts of mono-unsaturated homologues, all with the double bonds in (omega-9)-position.

Mono- and tetra-deprotonated 2-methylresorcinarene anions ( and ) as their trans-1,4-diammoniumcyclohexane inclusion complexes are reported. The mono-anion forms a fully closed dimeric capsule [·H2O·MeOH]2(2-) with a cavity volume of 165 Å(3) and as the guest with an extremely high packing coefficient, PC = 84.2%, while the tetra-anion forms a close-packed structure with two structurally isomer...

Gas-phase reactions of acylium ions with alpha,beta-unsaturated carbonyl compounds were investigated using pentaquadrupole multiple-stage mass spectrometry. With acrolein and metacrolein, CH(3)-C(+)(double bond)O, CH(2)(double bond)CH-C(+)(double bond)O, C(6)H(5)-C(+)(double bond)O, and (CH(3))(2)N-C(+)(double bond)O react to variable extents by mono and double polar [4 + 2(+)] Diels-Alder cycl...

Some new mono-and bis-polycyclic aromatic spiro-beta-lactams and bis-non spiro-polycyclic aromatic beta-lactams have been synthesized from imines derived from anthracene-9-carbaldehyde, 2-naphtaldehyde and a ketene derived from 9H-xanthene-9-carboxylic acid and phenoxyacetic acid by a [2+2] cycloaddition reaction. The cycloadducts were characterized by spectral data, including 1H-NMR, 13C-NMR, ...

new derivatives of 2-[2-(2-chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. in pharmacological evaluatio...