نتایج جستجو برای: 20 and 40 mg kg

تعداد نتایج: 16962964  

Journal: :Haematologica 2006
Antonio Piga Renzo Galanello Gian Luca Forni Maria Domenica Cappellini Raffaella Origa Antonietta Zappu Guido Donato Elena Bordone Antonella Lavagetto Laura Zanaboni Romain Sechaud Nicola Hewson John M Ford Herbert Opitz Daniele Alberti

BACKGROUND AND OBJECTIVES Iron accumulation is an inevitable consequence of chronic blood transfusions and results in serious complications in the absence of chelation treatment to remove excess iron. Deferoxamine (Desferal, DFO) reduces morbidity and mortality although the administration schedule of slow, parenteral infusions several days each week limits compliance and negatively affects long...

Journal: :iranian journal of pharmaceutical research 0
alireza abed department of pharmacology and toxicology, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran valiollah hajhashemi department of pharmacology and toxicology and pharmaceutical research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran hamid reza banafshe department of addiction studies, school of medicine, kashan university of medical sciences, kashan. iran. mohsen minaiyan 1department of pharmacology and toxicology and pharmaceutical research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran azam mesdaghinia physiology research center, kashan university of medical sciences, kashan. iran.

primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. this study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. we have evaluated the effect of caffeine, a non-sele...

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد علوم دارویی - دانشکده داروسازی 1392

هدف مطالعه حاضر بررسی اثر عصاره هیدروالکلی زردچوبه بر علایم سندرم محرومیت مورفین درموش سوری نر بود. در این مطالعه تجربی، 40 سر موش سوری نر نژاد nmri ( 20 الی 30 گرم) بطورتصادفی به 5 گروه 8 تایی تقسیم شدند: گروه کنترل مورفین و نرمال سالین(ml/kg 10)را دریافت نموده و بقیه گروه ها کلونیدین (mg/kg3/5 ) و دوزهای مختلف عصاره هیدروالکلی زردچوبه (mg/kg 25و50و100) را دریافت کردند. وابستگی به مورفین توسط ...

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

2014
Carlos Alberto Arcaro Vânia Ortega Gutierres Renata Pires Assis Thais Fernanda Moreira Paulo Inácio Costa Amanda Martins Baviera Iguatemy Lourenço Brunetti

Knowing that curcumin has low bioavailability when administered orally, and that piperine has bioenhancer activity by inhibition of hepatic and intestinal biotransformation processes, the aim of this study was to investigate the antidiabetic and antioxidant activities of curcumin (90 mg/kg) and piperine (20 or 40 mg/kg), alone or co-administered, incorporated in yoghurt, in streptozotocin (STZ)...

Journal: :Clinical and experimental immunology 2015
J E Ledgerwood E E Coates G Yamshchikov J G Saunders L Holman M E Enama A DeZure R M Lynch I Gordon S Plummer C S Hendel A Pegu M Conan-Cibotti S Sitar R T Bailer S Narpala A McDermott M Louder S O'Dell S Mohan J P Pandey R M Schwartz Z Hu R A Koup E Capparelli J R Mascola B S Graham

VRC-HIVMAB060-00-AB (VRC01) is a broadly neutralizing HIV-1 monoclonal antibody (mAb) isolated from the B cells of an HIV-infected patient. It is directed against the HIV-1 CD4 binding site and is capable of potently neutralizing the majority of diverse HIV-1 strains. This Phase I dose-escalation study in healthy adults was conducted at the National Institutes of Health (NIH) Clinical Center (B...

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease and stroke. However, the potential benefits of creatine for patients with convu...

Bhalsing Gaurav Vijay Bodhankar Subhash Laxamanrao Mali Vishal Ramahari Nandgude Tanaji Dilip Otari Kishor Vasant Shete Rajkumar Virbhadrappa,

     Colocasia esculenta Linn (CE) is traditionally used for the treatment of various ailments such as high blood pressure, rheumatic pain, pulmonary congestion, etc. Hence in present study, the effect of aqueous extract of CE leaves (AECE) was evaluated for antihypertensive and acute diuretic activity in rats. Preliminary phytochemical evaluation revealed the presence of carbohydrate, saponins...

Journal: Poultry Science Journal 2017
Abbasi M Afzali N Dastar B, Hashemi SR Shams Shargh M

This study was conducted to determine the effects of various doses and particle sizes (micro or nano) of dietary zinc and zinc oxide on growth performance, serum enzyme activities, carcass characteristics, and zinc requirements in Japanese quails. A total of 576 day-old Japanese quails (both sexes) were housed in 36 deep litter floor pens. Birds received a basal corn–soybean meal diet that was ...

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease and stroke. However, the potential benefits of creatine for patients with convu...

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