Novel genetically engineered mouse models using the Cre-loxP or the Flp-FRT systems have generated useful reagents to manipulate the mouse genome in a temporally-regulated and tissue specific manner. By incorporating a constitutive Cre driver line into a mouse model in which FRT-regulated genes in other cells types are regulated by Flp-FRT recombinase, gene expression can be manipulated simulta...

High performance self compacting concrete (HPSCC) is typically proportioned with mineral and chemical admixtures leading to relatively high material cost. Such cost can be tolerated in high value added applications specially when cost savings can be realized using HPSCC in terms of reduction in size of reinforced concrete members. Efforts are still needed to reduce material cost of HPSCC to gai...

Physio-chemical analysis of 200 soil samples collected from contaminated foci was investigated in six communities of Abua, Niger Delta Nigeria. The Jackson’s method was used in the chemical analysis of contaminated soils while Cobb’s decanting and sieving method was used in the extraction of geohelminths. The data showed that temperature, pH, Calcium (Ca), magnesium (mg), potassium (k) ions and...

Family assistance is an important aspect of family relationships for adolescents across many cultures and contexts. Motivations to help family members may be driven by both cultural factors and early family experiences. Here, we used fMRI to examine (1) cultural differences in neural reward activity among White and Latino youth during online experiences of family assistance and (2) how prior fa...

Cellular thiols are critical moieties in signal transduction, regulation of gene expression, and ultimately are determinants of specific protein activity. Whilst protein bound thiols are the critical effector molecules, low molecular weight thiols, such as glutathione, play a central role in cytoprotection through (1) direct consumption of oxidants, (2) regeneration of protein thiols and (3) ex...

Craving of unhealthy food is a common target of self-regulation, but the neural systems underlying this process are understudied. In the present study, participants used cognitive reappraisal to regulate their desire to consume idiosyncratically craved or not craved energydense foods, and neural activity during regulation was compared to each other and to activity during passive viewing of ener...

Sexual experience has marked and long-lasting effects on male behavior in mammals, regulating traits such as the anticipation and display of sexual behavior, aggression and olfaction. We conducted urine preference, habituation-dishabituation and partner choice tests with sexually experienced and naïve male mice and found that wild-type males acquire adaptively significant preferences for the od...

Recent studies have revealed that diverse cell types use mRNA localization as a means to establish polarity. Despite the prevalence of this phenomenon, much less is known regarding the mechanism by which mRNAs are localized. The Drosophila oocyte provides a useful model for examining the process of mRNA localization. oskar (osk) mRNA is localized at the posterior of the oocyte, thus restricting...

We have further defined mechanism(s) by which OSU-03012 (OSU), a derivative of the COX2 inhibitor Celecoxib but lacking COX2 inhibitory activity, kills transformed cells. In cells lacking expression of PKR-like endoplasmic reticulum kinase (PERK -/-) the lethality of OSU was attenuated. OSU enhanced the expression of Beclin 1 and ATG5 and cleavage of pro-caspase 4 in a PERK-dependent fashion an...

Adcock, G.J. and Billing, T.M. and Carew, P.J. and Mulder, R.A. and Kraaijeveld, K. Department of Zoology, University of Melbourne, Melbourne 3010, VIC and Department of Biology, Darwin Building, UCL, Gower Street, London WC1E 6BT United Kingdom Mate choice and dispersal history within a population of the mutually ornamented black swan. Dispersal and mating behaviour were examined in the Lake W...