Abstract MicroRNA-21 (miR-21) is upregulated in SLE patients and promotes disease multiple autoimmune mouse models; however, mechanisms by which miR-21 promote autoimmunity are unknown. Here we show that TLR7 overexpressing SLE-prone B6.Sle1b Yaamice deficient (Sle1b YaamiR-21 −/−) resisted development through reduced germinal center (GC) B cell, T follicular helper plasma cell responses. Sle1b...

OBJECTIVE To determine prevalence and intensity of pain after stroke, focusing on patients' perspectives. METHODS During a one year period, 416 first-ever stroke patients were included in the population based Lund Stroke Register. After 4 and 16 months (median), 297 patients (98% of survivors) were followed up. Worst pain intensity during the previous 48 hours was assessed on a visual analogu...

Received 21 December 2017 Revised 7 February 2018 Accepted 8 March 2018 AbstrAct The bone alignment of the metacarpophalangeal joint (MPJ) of the distal interphalangeal joint (DIPJ) in metacarpophalangeal flexural deformity (MPFD) in calves was evaluated by radiography. This study was designed by retrospective study of radiographs. Lateral to medial radiographs of distal forelimbs were taken fr...

Thirty-two weeds commonly found in the organic soils of southwestern Quebec were evaluated for host suitability to a local isolate of the northern root-knot nematode Meloidogyne hapla under greenhouse conditions. Galls were observed on the roots of 21 species. Sixteen of the 21 had a reproduction factor (Pf/Pi = final number of M. hapla eggs and juveniles per initial number of M. hapla juvenile...

This study evaluated the efficacy and safety of adding etanercept to disease-modifying antirheumatic drugs (DMARDs) in patients with moderately active rheumatoid arthritis (RA). This randomized, double-blind, placebo-controlled study (ClinicalTrials.gov #NCT01313208) enrolled RA patients with Disease Activity Score using 28 joints with C-reactive protein (DAS28-CRP) >3.2 and ≤5.1 (moderate dise...

We hypothesized that a short-term training program involving repeated all-out sprint training (RST) would be more effective than work-matched, low-intensity endurance training (ET) in enhancing the kinetics of oxygen uptake (Vo(2)) and muscle deoxygenation {deoxyhemoglobin concentration ([HHb])} following the onset of exercise. Twenty-four recreationally active subjects (15 men, mean +/- SD: ag...

Most of the benefic effects of negative air ions (NAI) quoted in the literature until the end of the 20 century were obtained with high doses of NAI, but at these doses a phased action was noted: favorable at the beginning, then unfavorable on extended exposures. In Romania, experimental studies on animal or human subjects were made mostly with moderate doses of air ions, close to those in the ...

Allergic rhinitis (AR) is the most common allergic disease. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify AR according to its duration and severity and suggest recommended treatments, but there is evidence that these guidelines are insufficiently followed. Considering the validity of histopathological data, physicians are more likely to be persuaded by such informati...