[3H]Squalene 2,3(S);22(S),23-dioxide was prepared by incubation of [3H]mevalonate with S10 rat liver homogenate in the presence of 4,4,10 beta-trimethyl-trans-decal-3 beta-ol, a specific inhibitor of oxidosqualene cyclase (EC 5.4.99.7). Aerobic incubation of [3H]squalene 2,3(S);22(S),23-dioxide with S10 rat liver homogenate affords 24(S),25-epoxycholesterol with an efficiency comparable to that...

Coastally trapped wind reversals (CTWRs) occur periodically in the marine boundary layer off the western coast of the United States and dramatically change the low-level wind regime and coastal weather. Southerly flow becomes established with the passage of a CTWR along with cooler temperatures and a low stratus deck in a narrow band along the coast. CTWRs can propagate northward along the coas...

OBJECTIVES To compare the frequency of headache and the procedure time following lumbar puncture (LP) using a 25-gauge needle compared to a 22-gauge needle. DESIGN 4-period crossover blinded randomised controlled trial. SETTING Oncology unit, Royal Children's Hospital, Melbourne. PATIENTS Children aged 4-15 years at enrolment having LPs as part of their treatment for leukaemia. INTERVEN...

SAGISAKA, K. and TOKIWA, K . MN Blood Group Activity of the Blood Components Other Than the Red Cells. Tohoku J. exp. Med., 1973, 109 (1), 1-6 The presence of M and N antigens in the blood components other than the red cells and various tissues has not been settled yet . The elution method in combination with antiglobulin test reported by the present authors has been used for grouping the stain...

A child with many symptoms of trisomy 22 syndrome is described. The child showed a 46,XY/47,XY,+22 chromosome constitution. This is the first reported case of a trisome 22 phenotype with such a mosaic karyotype.

To investigate the influence of N- or C-terminal regions of pleurocidin (Ple) peptide on the antifungal activity, four analogues partially truncated in the N- or C-terminal regions were designed and synthesized. Circular dichroism (CD) spectroscopy demonstrated that all the analogues maintained an alpha-helical structure. The antifungal susceptibility testing also showed that the analogues exhi...