[3H]Squalene 2,3(S);22(S),23-dioxide was prepared by incubation of [3H]mevalonate with S10 rat liver homogenate in the presence of 4,4,10 beta-trimethyl-trans-decal-3 beta-ol, a specific inhibitor of oxidosqualene cyclase (EC 5.4.99.7). Aerobic incubation of [3H]squalene 2,3(S);22(S),23-dioxide with S10 rat liver homogenate affords 24(S),25-epoxycholesterol with an efficiency comparable to that...

introduction: d-galactose (d-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. in the present study, we selected crocin, the main constituent of crocus sativus l. (saffron), against d-gal cytotoxicity in human neuroblastoma sh-sy5y cells. materials and methods:  cells were pretreated with crocin (25-500 µm) for 24 h and then exposed to d-gal...

One new cycloartane-type saponin, 3-O-[β-D-xylopyranosyl-(1→2)-β-D-xylopyranosyl]-6-O-β-Dglucuronopyranosyl-3β,6α,16β,24(S),25-pentahydroxyxyxloartane (1) was isolated from the MeOH extract of whole plant parts of Astragalus erinaceus along with 5 known saponins (2-6), cyclodissectoside, cycloastragenol, 6-O-β-D-glucopyranosyl-3β,6α,16β,24(S),25-pentahydroxycycloartane, oleifolioside B and 3,6d...

Tomato (Solanum lycopersicum) is a model plant of the Solanaceae family. Various biological aspects of tomato have been investigated with molecular biological approaches, and a significant amount of DNA and protein sequencing data on tomato has been accumulated. Recently, the number of tomato genome sequences in the International Nucleotide Sequence Databases has been rapidly increasing due to ...

background: the degree to which the amount of aningested nutrient is absorbed and available to the body is calledbioavailability. objectives: relative effectiveness of herbalmethionine (h-met®) compared to dl-methionine (dl-met)was investigated in this experiment. methods: exponentialregression analysis was used to determine bioefficacy of h-met®based on body weight gain, feed intake and feed c...

CONTEXT A number of controversies exist regarding appropriate treatment strategy for Vitamin D deficiency. AIMS The aim of this study was to investigate the efficacy of equivalent doses of oral cholecalciferol (60,000 IU weekly for 5 weeks) versus intramuscular (IM) cholecalciferol (300,000 IU) in correcting Vitamin D deficiency in apparently healthy volunteers working in a hospital. SETTIN...

The efficiency of 2 enzyme complexes on male broiler nutrient digestibility and performance were evaluated. A total of 120 and 840 day-old male broilers (Cobb 500 strain) were used in the metabolic and performance tests, respectively. The birds were distributed into 4 treatments [positive control (PC), negative control (NC), NC + enzyme complex A (xylanase, glucanase, amylase, protease and cell...

BACKGROUND The three main vitamin D metabolizing enzymes, vitamin D3-25-hydroxylase (25-OHase, 25-hydroxylase), 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-OHase, 1alpha-hydroxylase) and 25-hydroxyvitamin D3-24-hydroxylase (24-OHase, 24-hydroxylase), have been described in malignant breast tissue. This in vitro study aimed to obtain more information regarding the regulation of these enzymes...