OBJECTIVE Studies based on deseasonalized vitamin D levels suggest that vitamin D may influence the disease activity in multiple sclerosis (MS), and high doses are suggested as add-on treatment to interferon-β (IFN-β). Seasonal fluctuation of vitamin D varies between individuals, thus the relationship to disease activity should preferentially be studied by repeated and simultaneous vitamin D an...

A liquid chromatography tandem mass spectrometry method for 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 from human plasma has been developed. Sample preparation was fast and efficient using a Thermo ScientificTM SOLATM hydrophobic reversed phase (HRP) plate. Analysis was carried out using a Thermo ScientificTM SyncronisTM C18 1.7 μm, 50 × 2.1 mm column to give a fast separation with a cycle t...

The decreased absorption of calcium by the small intestine of the adult may reflect changes in vitamin D metabolism with age. The purpose of this study was to compare the capacity of young (1.5 mo of age) and adult (12 mo of age) vitamin D-deficient rats to convert 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D, the physiologically active form of vitamin D. Young rats responded to an oral dose ...

Background Neonatal sepsis is a critical condition caused by a generalized bacterial infection in the first month of life. The present study aimed to investigate the relationship between serum vitamin D levels and neonatal sepsis. Materials and Methods: A search of online databases (Medl...

BACKGROUND AND OBJECTIVES With an increased incidence of obesity in China, this study sought to investigate the correlation between serum 25-hydroxyvitamin D levels and adiposity phenotypes in Chinese adults from urban settings. METHODS AND STUDY DESIGN A total of 1277 subjects aged 20-82 years old were recruited into this cross-sectional study. Anthropometric parameters and blood biochemistr...

PURPOSE To investigate the association between blood 25-hydroxyvitamin D levels and pterygium. METHODS Korean National Health and Nutrition Examination Survey 2008-2011 were used for the present epidemiologic study. A total of 19,178 participants aged ≥ 30 years were evaluated for blood 25-hydroxyvitamin D levels and performed ophthalmic slit lamp examinations. Pterygium was considered as a g...

BACKGROUND Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. OBJECTIVE To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic. DESIGN A Mendelian randomization study was undertak...

Anticonvulsant therapy of seizure disorders in man is associated with the development of complications involving bone and mineral metabolism including hypocalcemia, elevated serum immunoreactive parathyroid hormone levels, and increased amounts of unmineralized bone or osteoid. The latter has been attributed to a reduction in serum-25-hydroxycholecalciferol levels resulting from increased hepat...

We aimed to describe the vitamin D status of young women living in two Chinese cities in the spring--Beijing in the north (latitude 39 degrees north) and Hong Kong (latitude 22 degrees north) in the south. We also examined the relationship between serum 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations to determine a threshold for serum 25-hydroxyvitamin D above which there is no...