Unsaturated aliphatic isobutylamides from Asteraceae, Rutaceae and Piperaceae are potential agents to control schistosomiasis. Affinin (N-isobutyl-2,6,8_decatrienamide) from Heliopsis longipes has strong molluscicidal activity against Physa occidentalis (LD5e ca 100 PM) and the cercariae of the fluke. The amide has also been shown to be present in Wedelia parviceps flowers.

Much human learning appears to be gradual and unconscious, suggesting a very limited form of search through the space of hypotheses. We propose hill climbing as a framework for such learning and consider a number of systems that learn in this manner. We focus on CLASSIT, a model of concept formation that incrementally acquires a conceptual hierarchy, and MAGGIE, a model of skill improvement tha...

DNA cross-linking technology is an attractive tool for the detection, regulation, and manipulation of genes. In this study, a series of photolabile 4-oxo-enal-modified oligonucleotides functionalized with photosensitive ο-nitrobenzyl derivatives were rationally designed as a new kind of photocaged cross-linking agents. A comprehensive evaluation of cross-linking reactions for different nucleoba...

The most studied combinatorial optimization problem in transport and logistics is the vehicle routing problem (VRP). The goal of the vehicle routing problem is to nd a set of routes for a eet of vehicles which optimises the objective function (e.g. total distance, routing costs). Every demand needs to be ful lled and vehicle capacities need to be respected. Many solution methods exist for the '...

The Vehicle Routing Problem (VRP) is a class of well-known NP-hard combinatorial optimisation problems. The VRP is concerned with the design of the optimal routes, used by a fleet of identical vehicles stationed at a central depot to serve a set of customers with known demands. In the basic version of the problem, known as a Capacitated VRP (CVRP), only capacity restrictions for vehicles are co...

Misdiagnoses and missed diagnoses of gifted students with co-occurring learning-, developmental behavioural disorders are often mentioned in literature practice. Consequently, these Twice-Exceptional (2E) fall between two stools regarding appropriate psycho-educational interventions. This article offers a research practice informed assessment procedure, namely the Strengths Weaknesses Heuristic...