where Ω is an open and bounded domain with smooth boundary, ∇̂u denotes the strain tensor, ∇̂u := 12 (∇u + (∇u)T ), ψ ∈ H(∂Ω) is the boundary displacement or source, and C ∈ L(Ω) denotes the isotropic elasticity tensor with Lamé parameters λ, μ: C = λI3 ⊗ I3 + 2μIsym, a.e. in Ω, where I3 is 3 × 3 identity matrix and Isym is the fourth order tensor such that IsymA = Â, ρ ∈ L(Ω) is the density, and...

Prostaglandin E2 (PGE2) is a proinflammatory lipid mediator that promotes cancer growth. The 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes oxidation of the 15(S)-hydroxyl group of PGE2, leading to its inactivation. Therefore, 15-PGDH induction may offer a strategy to treat cancers that are driven by PGE2, such as human cholangiocarcinoma. Here, we report that omega-3 polyunsaturated...

Understanding the importance of dietary fat has grown beyond energy metabolism to recognition of the complex roles of fatty acids, particularly the ω-6 and ω-3 fatty acids in membrane lipids, inter- and intracellular communication and in regulating gene expression. The ω-6 and ω-3 fatty acids accumulated in developing tissues depend on the fatty acids transported across the placenta and secrete...

The anemia of sickle cell disease is associated with a severe inflammatory vasculopathy and endothelial dysfunction, which leads to painful and life-threatening clinical complications. Growing evidence supports the anti-inflammatory properties of ω-3 fatty acids in clinical models of endothelial dysfunction. Promising but limited studies show potential therapeutic effects of ω-3 fatty acid supp...

Protein isolate was recovered from whole gutted fish using isoelectric solubilisation/precipitation (ISP). The objective was to determine chemical properties of heat-set gels made of the ISP protein isolate fortified with ω-3 polyunsaturated fatty acids (PUFAs)-rich oils (flaxseed, fish, algae, krill, and blend). The extent of the PUFAs increase, ω-6/ω-3 FAs and unsaturated/saturated FAs ratios...

During the last years the evidence of the nutritional benefits of polyunsaturated fatty acids (PUFA), especially omega-3 fatty acids, in the human body has become established. Moreover, the nutrition experts have recently recommended to increase the PUFA consumption in order to maintain an omega-6/omega-3 ratio between 5:1 and 10:1 in the diet [1]. Fish is the major dietary source of ω-3 PUFA; ...

We investigate the expressive power of timing restrictions on labeled transition systems. In particular, we show how constraints on clock variables together with a uniform liveness condition| the divergence of time|can express B uchi, Muller, Streett, Rabin, and weak and strong fairness conditions on a given labeled transition system. We then consider the e ect, on both timed and time-abstract...

Purpose To evaluate the therapeutic effects of omega-3 (ω-3) and omega-6 (ω-6) fatty acids in the CCL2-/- model of dry age-related macular degeneration (AMD). The blood level of eicosapentaenoic acid (EPA) and arachidonic acid (AA) served to adjust the treatment dosage (AA/EPA=1-1.5). Methods Nine-month-old animals were allocated to different groups: (A) C57BL/6 untreated , (B) CCL2-/- untrea...

Despite the well-documented health benefits of ω-3 polyunsaturated fatty acids (PUFAs), their use in clinical management of hyperglycemia and obesity has shown little success. To better define the mechanisms of ω-3 PUFAs in regulating energy balance and insulin sensitivity, we deployed a transgenic mouse model capable of endogenously producing ω-3 PUFAs while reducing ω-6 PUFAs owing to the exp...