1. Dysregulated vascular endothelial growth factor (VEGF) expression has been reported in several pathological states based upon evidence of elevated serum VEGF levels. Using two immunoassays for VEGF, this study determines normal plasma and serum VEGF ranges, determines which are more likely to reflect circulating VEGF levels and investigates a potential contribution of VEGF from platelets to ...

1. Within certain limits the clotting time of blood, of blood plasma, and of solutions of fibrin to which bile salts have been added, is proportional to the quantity of bile present. 2. The bile interferes with the conversion of fibrinogen into fibrin and not with the formation of thrombin.

with the following parameter changes: Sample volume 40 pipetting 2.0 mL of FFP into the calcium-adulterated ACT 4; Diluent volume 14 L; Calculation mode 0. When tube, and treat it as if it were a patient’s sample. modified as above, results are reported in milligrams per The precision ofthe FFP and AP’N’ systems is tabulated liter and cover the range 1.7-54.5 mg ofalbunun per liter. below: We a...

As judged from thrombotest dilution curves clotting inhibiting material was present in 67% of human umbilical cord plasma samples of healthy full term infants (n = 40). The correlation coefficient (r-value) between the thrombotest clotting times and the prothrombin levels was -0.46. Using sensitive enzyme immuno assays for fibrin degradation products (FbDP) and fibrinogen degradation products (...

Activated Clotting Time (ACT) has been the standard for monitoring heparin anticoagulation in cardiac surgery for three decades. Although a 10% coefficient of variation (CV) is the referenced standard for the test, no recent reports of precision are available. The precision of Hemochron FTCA510 (celite) and KACT (kaolin) ACT test tubes was evaluated using a retrospective analysis of results fro...

We studied the coagulation of plasma by thrombinwith a titration calorimeter at 20 #{176}C. When thrombin is added to plasma, three distinct alterations in the thermal pattern are seen. The precoagulation region is generally exothermic, although occasionally, with some plasmas, cooling is observed. The coagulation region is defined by a sharp exotherm, a plateau, and then a sharp endotherm. Pos...

The objective of this research was to compare the effect of 2 fungal proteases, one that is already commercially established as a milk-clotting agent and another produced at the laboratory scale, on Prato cheese composition, protein and fat recovery, yield, and sensory characteristics. Cheeses were produced according to the traditional protocol, using protease from the fungus Thermomucor indica...

Experimental hypercalcaemia was induced in rats by (1) transplantation of the solid Walker 256 tumour, and (2) intraperitoneal injections of calcium gluconate. Whole blood clotting was studied by means of thromboelastography and whole blood clotting times in polystyrene and glass test tubes. At serum calcium levels between 10.3 and 11.5 m-equiv/l a slight delay in clot formation was found which...

In this work the suitability of some Tibased coatings as coating for blood-contacting implants is analyzed. Layers of pure Ti, Ti nitride, Ti oxynitrides (TiN1-xOx with x = 0.25, 0.50, and 0.75) and Ti oxides were deposited from a plasma produced by cathodic arc evaporation under addition of N2 and/or O2. The oxynitrides are crystalline with the fcc structure of TiN up to x = 0.25. For x = 0.5 ...

The effect of chronic administration of variable low doses of Aspirin was studied on platelet adhesiveness, platelet count, bleeding time and clotting time to find out as to how low the dose of aspirin needs to be in order to have an effective antiplatelet effect in patients who require such therapy. A statistically significant reduction in the platelet adhesiveness was observed in all the grou...