When weanling rats are reared on a fat-free diet for about 10 weeks they develop, as originally shown by Burr & Burr (1929), certain signs of a nutritional deficiency. The signs can be cured or prevented by the inclusion of essential fatty acids (EFA), as linoleic acid, in the diet and the condition is therefore termed EFA deficiency. The weanling male rat has been used extensively in studies c...

Vitamin B-6 deficiency has been reported to alter n-6 and n-3 fatty acid profiles in plasma and tissue lipids; however, the mechanisms underlying such metabolic changes remain unclear. The objective of this study was to determine the effects of vitamin B-6 restriction on fatty acid profiles and fatty acid synthesis in HepG2 cells. Cells were cultured for 6 wk in media with four different vitami...

Deficiency in long-chain omega-3 (LCn - 3) fatty acids, eicosapentaenoic acid (EPA, 20:5n - 3) and docosahexaenoic acid (DHA, 22:6n - 3), has been implicated in the pathoetiology of cardiovascular disease, a primary cause of excess premature mortality in patients with schizophrenia (SZ). In the present study, we determined erythrocyte EPA + DHA levels in adult medication-free patients SZ (n = 2...

Based on dietary intake recommendations, magnesium deficiency commonly occurs throughout the world. However, widespread pathological conditions induced by dietary magnesium deficiency have not been identified. This discrepancy may be caused by other dietary factors ameliorating or exacerbating the response to a marginal magnesium deficiency and/or the length of the deficiency. Thus, a study was...

This study was conducted to determine optimal ratios of dietary linolenic acid (18:3n-3, LnA) to linoleic acid (18:2n-6, LA) for Tor tambroides. Juveniles were fed three trial diets with different ratios of LnA/LA (0.0, 0.5 and 1.0) for 10 weeks. Another diet contained 100% palm oil, which was similar tothe diet with 0.0 LnA/LA ratio but different in total amounts of C18polyunsaturated fatty ac...

It was found recently (1) that feeding a cholesterol-rich diet to pantothenic acid-deficient rats did not result in the fatty livers and high levels of cholesterol in liver and serum seen in comparable animals maintained on a normal diet. Decrease in food intake appeared not to account for this phenomenon, since the food intake of the deficient group on a body weight basis was higher than that ...

background: dietary risk factors constitute some of the leading risk factors for cardiovascular disease in iran. the current study reports the burden of ischemic heart disease (ihd) attributable to a low omega-3 fatty acids intake in iran using the data of the global burden of disease (gbd) study 2010. methods: we used data on iran for the years 1990, 2005, and 2010 derived from the gbd study c...