In the present study, a series of 2-(3'-substituted-2'-hydroxypropylamino)pyridines were synthesized and characterized by IR, 1H-NMR and elemental analysis. The compounds were investigated for anticonvulsant (150, 300 mg/kg) and cardiac activity. 2-(3'-Diethylamino-2'-hydroxypropylamino)pyridine 3 was found to exhibit the highest anticonvulsant activity. 2-(3'-Dimethylamino-2'-hydroxypropylamin...

Fluorescence properties of hydroxy-naphthalimides were studied in methylene chloride in the absence and the presence of hydrogen-bonding additives. The position of the HO-substituent only slightly a†ects the radiative rate, however, the triplet yield and the rate of the radiationless processes are considerably higher for the 3-hydroxy derivative. Addition of nitrogen-heterocyclic compounds lead...

Quinoline based new Schiff bases were synthesized from 3-Actyl 4-Hydroxy Quinolin-2-(1H)-one and screened their antibacterial antifungal activity. The 4-hydroxy-3-(1-((4-picolin-2-yl)imino)ethyl)quinolin-2-(1H)-one(L1),4-hydroxy-3-(1-((5-picolin-2-yl)imino)ethyl)quinolin-2(1H)-one(L2),4-hydroxy-3-(1-((6-picolin-2-yl)-imino)ethyl)quinolin-2(1H)-one(L3) 4-hydroxy-3-(1-((3-nitro-4-picolin-2-yl)imi...

In this study, we characterized a muscarinic acetylcholine receptor (mAChR) potentiator, LY2119620 (3-amino-5-chloro-Ncyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy] thieno[2,3-b]pyridine-2-carboxamide) as a novel probe of the humanM2 and M4 allosteric binding sites. Since the discovery of allosteric binding sites on G protein–coupled receptors, compounds targeting these novel s...

The syntheses of two new spirolactones are described. Each compound was obtained as an off-white solid in 66% yields from 4-hydroxy-3-nitrobenzaldehyde.