Abstract: 5,5 ′ -Methylenebis(4–phenyl-4H -1,2,4-triazole-3-thiol) (2) was synthesized starting from hydrazinecarbothioamide compound (1). Treatment of compound 2 with ethyl bromoacetate produced diethyl 5,5 ′ -{methylenebis[(4phenyl-4H -1,2,4-triazole-5,3-diyl)thio]}diacetate (3), which was converted to the corresponding diacetohydrazide derivative (4) by treatment with hydrazine hydrate. The ...

Regioselective synthesis of quinolone-1,2,4-triazoles was established starting from 4-hydroxyquinol-2-ones. The strategy started by the reaction ethyl bromoacetate with 4-hydroxyquinoline to give corresponding oxoquinolinyl acetates, which reacted hydrazine hydrate afford hydrazide derivatives. Subsequently, hydrazides isothiocyanate derivatives acyl thiosemicarbazides. Finally, subjecting thio...

In the title compound, C(29)H(24)N(4)O(2)S, intra-molecular O-H⋯N hydrogen bonding influences the mol-ecular conform-ation; the naphthol system and triazole ring form a dihedral angle of 3.88 (7)°. In the crystal, π-π inter-actions between the five- and six-membered rings of neighbouring mol-ecules [centroid-centroid distances = 3.541 (3) and 3.711 (3) Å] consolidate the crystal packing.

In this work, the 1,2,4-triazole ring was prepared by introducing starting material ortho-carboxybenzaldehyde (1) in usual esterification reaction, ethanol as a solvent and presence of concentrated sulfuric acid to give ethyl-2-formylbenzoate (2), then resulting ester condensation reaction with thiosemberazide afforded 2-(2-formylbenzoyl)hydrazine-1-carbothioamide (3), which on cyclisation usin...