Electrochemical behavior of I-hydroxypyridine-2-thione and its vanadium complex is studied using polarographic techniques. Polarograms of ligand and that of the complex is shown with diffusion characteristics of the waves. Cyclic voltagram of thione is investigated which shows that a reversible oxidation reduction of one electron process is taking place. PKa of the thione is found to be in ...

The study of Human immunodeficiency virus (HIV) in humans and animal models in last 31 years suggested that it is a causative agent of AIDS. This causes serious pandemic public health concern globally. It was reported that the HIV-1 reverse transcriptase (RT) played a critical role in the life cycle of HIV. Therefore, inhibition of HIV-1RT enzyme is one of the major and potential targets in the...

Many new mixed ligand complexes of mercury(II) have been synthesized with LH = 4,5-(diphenyl)-1,2,4-triazole-3-thione (diptSH) and tertiary phosphines as co-ligands. The compounds characterized by elemental analyses, IR, UV–Vis, molar conductivity, NMR spectroscopy. In the binuclear (2-5), both Hg atoms tetrahedral geometry, atom bonded to three halide ions one thione (LH) through sulfur atom. ...

The binding of three closely related chelators: 5-hydroxy-2-methyl-4H-pyran-4-thione (allothiomaltol, ATM), 3-hydroxy-2-methyl-4H-pyran-4-thione (thiomaltol, TM), and 3-hydroxy-4H-pyran-4-thione (thiopyromeconic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated. Two of these ligands display a monodentate mode of coordination to the active site Zn(2+) io...

l,2-Dithiol-3-thiones, reported constituents of cruciferous vegetables, are five-membered cyclic sulfur-containing compounds with antioxidant, chemotherapeutic, and chemoprotective activities. The effects of dietary administration of a substituted l,2-dithiol-3-thione, oltipraz |5-( 2-pyrazinyl)-4-inethyl-l,2-dithiol-3-thione|, a potent antischistosomal agent, on »fiatimi! BI (AFBi) metabolism...