Vaso-occlusion is a hallmark of sickle cell disease. Agonist-induced activation of sickle red blood cells (SS RBCs) promotes their adhesion to vascular proteins, potentially contributing to vasoocclusion. Previously, we described a cyclic adenosine monophosphate (cAMP)–dependent increase in SS RBC adhesion to laminin. Here, we investigated whether Rap1, a small guanosine triphosphatase (GTPase)...

BACKGROUND Although the prevalence of adolescents' cigarette smoking has increased in recent decades, little is known regarding its epidemiology in certain Saudi regions, including the Madinah region. The aim of this study was to determine the prevalence and predictors of adolescent cigarette smoking in Madinah, Saudi Arabia. METHODS A school-based cross-sectional study was carried out in the...

INTRODUCTION The implementation of highly active antiretroviral therapies (HAART) has reduced the mortality attributed to the human immunodeficiency virus (HIV) infection. Variation in the specific causes of death has also changed since the implementation of these therapies. METHODS A prospective study was performed in 3322 HIV-infected persons enrolled in Puerto Rico between 1992 and 2003. W...

This paper presents the main characteristics of Logic Models Creator (LMC). LMC is a new educational environment for young students to build and explore logic models in graphical form. LMC allows visual representation of logic models using IF/THEN/ELSE constructs. In this paper we provide an overview of LMC architecture and discuss briefly an example of use of LMC. As discussed, LMC users in th...

Some heterodox economists, most notably Tony Lawson, have come under suspicion of not being true pluralists, but ‘strategic pluralists’: their advocacy of pluralism is thought to be merely instrumental to a hidden monist agenda. This paper does not aim to judge the accused but rather to assess the accusations; the focus is on clarifying the notion of pluralism itself. First a paradox is found t...

&1 Emilia den Boer Dr-Ing Assistant Professor, Wrocław University of Technology, Institute of Environment Protection Engineering, Wroclaw, Poland &2 Ian D. Williams BSc, PGCE, PhD, CChem, MRSC, MCIWM, FHEA Professor of Applied Environmental Science, Centre for Environmental Sciences, Faculty of Engineering and the Environment, University of Southampton, Southampton, UK &3 Tony Curran BSc, MRes,...

At the 2005 AMSRS Conference, Paul won the Tony Wheeler Best Paper Award for his compelling story “Research as a Life Changing Experience” demonstrating the impact that research can have with numerous case studies that included breakthrough thinking. Paul spoke at the 2006 AMI Government Marketing Conference with a talk entitled “Community Engagement: Where There’s a Will, There’s a Way”. He wa...

Neurobrucellosis (N.B) is a rare and severe form of systemic Brucella infection. We introduced an unusual case that “Psychologic Symptoms” was the most prominent complaints of his family. He was a 50-year-old man who has worked in butchery. His problems had begun 2 months prior to his admission with mood disorders, arthralgia, weakness, headache, and night sweats; he has recurrent crying with n...

Background: The clinical presentation of non-Hodgkin lymphoma (NHL) varies tremendously depending upon the type of lymphoma and the areas of involvement. NHL can rarely present as an abdominal mass compressing the inferior vena cava. The clinical presentation due to obstruction of inferior vena cava has often been called the inferior vena cava syndrome (IVCS). It can present acutely or chronica...