New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxyl-2-methylpropanoic acid (9aA: AHL-157) showed very superior activities in decreasing triglyceride, cholesterol, and blood sugar compared to bezafibrate in mice and rats.

In the title compound, C15H17N3O, the aldehyde group is twisted relative to the quinoline group by17.6 (2)° due to the presence of a bulky piperazinyl group in the ortho position. The piperazine N atom attached to the aromatic ring is sp (3)-hybridized and the dihedral angle between the mean planes through the the six piperazine ring atoms and through the quinoline ring system is 40.59 (7)°. Bo...

In the title compound, [Cd(ClO(4))(2)(C(15)H(18)N(4))(4)], the Cd(II) ion is coordinated in a slightly distorted octa-hedral environment by two trans monodentate perchlorate ligands and four 1-(2-pyrid-yl)-4-(4-pyridylmeth-yl)piperazine (pmpp) ligands. In the crystal structure, mol-ecules are organized into layers parallel to the ab plane by C-H⋯O inter-actions. Similar inter-actions promote th...

Male strain A mice were given 0.69-18.75 g piperazine/kg Food and 0.05-2.0 g sodium nitrite (NaN02)/liter drinking water For 20-25 weeks, and were killed 10-13 weeks later. The yield of lung adenomas was significantly greater than in untreated controls when as liHle as 0.69 9 piperazine/kg plus 1.0 9 NaNOdliter, or 6.25 9 piperazine/kg plus 0.25 9 NaN02/liter, were given. A maximum of 30.7 aden...

Abstract Here, we report the results of experiments regarding chemical repositioning 4‐(2‐hydroxyethyl)‐1‐piperazine ethane sulfonic acid ( HEPES ), a representative buffering agent. In this work, confirmed that could disaggregate amyloid plaques, hallmark Alzheimer's disease, and verified its sustained‐release system (release for up to 2 weeks) via hybridization with biocompatible polymer (Eud...

In the title salt, C(26)H(27)F(2)N(2) (+)·C(4)H(5)O(4) (-), the piperazine N atom bearing the vinylic substituent is protonated. The piperazine ring adopts a chair conformation. In ther crystal, the succinate monoanions are connected via short O-H⋯O hydrogen bonds between the carb-oxy-lic acid and carboxyl-ate groups into undulating chains extending along [001] and the flunarizinium monocations...

In the title compound, C(13)H(16)ClFN(2)O, the piperazine ring is flanked by 1-(2-fluoro-benz-yl)piperazine and adopts a chair conformation. The dihedral angle between the fluoro-phenyl ring and the four planar C atoms (r.m.s. = 0.0055 Å) of the piperazine chair is 78.27 (7)°, whereas the dihedral angle between the four planar C atoms of the piperazine chair and the ethanone plane is 55.21 (9) ...

The crystal structures of the title 1,4-bis(4-cyanobenzyl)piperazine (1) and 1,4-bis(4-amidinobenzyl)piperazine tetrahydrochloride tetrahydrate (2) are reported. Compound (1) crystallizes in the triclinic space group P\bar 1 and compound (2) in the monoclinic space group P21/n. In both (1) and (2) the asymmetric unit contains one half of the molecule because the central piperazine rings were lo...

In the title compound, C(22)H(24)N(4)O, the aromatic moiety is essentially planar (r.m.s. deviation of a least-squares plane fitted through all non-H atoms = 0.0386 Å) and is rotated by 89.98 (4)° from the piperazine ring, which adopts the expected chair conformation. The propanol chain is not fully extended away from the piperazine ring. In the crystal, there are two unique hydrogen-bonding in...

The title compound, 2C(21)H(19)N(3)O(2)·H(2)O, was synthesized by a Schiff base condensation of 2,6-diformyl-pyridine with 2-amino-4-methyl-phenol in ethanol. In the crystal, two mol-ecules of 2,6-bis-[(2-hy-droxy-5-methyl-phen-yl)imino-meth-yl]pyridine dimer-ize via hydrogen bonding to a water mol-ecule, which lies on a twofold axis. There are also intra-molecular phenol-imine hydrogen bonds. ...