Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in pr...

A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized ((1)H NMR, (13)C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon c...

In the title compound, C12H9BrN4O, the N'-methyl-idene-pyrazine-2-carbohydrazide and 4-bromobenzene groups are oriented at a dihedral angle of 10.57 (7)°. The hydrazide N-H group is involved in intra-molecular N-H⋯N inter-action, which generates an S(5) motif. A short C-H⋯O inter-action is formed between the methyl-idene H atom and the carbonyl O atom. It connects mol-ecules into chains extendi...

In the crystal structure of the title compound, C(11)H(15)N(3)O(3), mol-ecules are linked into a chain by inter-molecular N-H⋯O hydrogen bonds.

The crystal structure of the title compound, C(14)H(13)N(3)O(3), exhibits two inter-molecular N-H⋯O hydrogen bonds.

In the title compound, C(13)H(9)F(2)N(3)O, the pyridine ring forms a dihedral angle of 16.92 (7)° with the benzene ring. In the crystal, mol-ecules are linked via N-H⋯O, C-H⋯O and C-H⋯F, with the same O atom accepting two bonds.