Tertiary piperazine aminoalcohols were synthesized by reacting 1-(4-butoxyphenyl)-3-(4-substituted piperazin-1-yl)-2-phenylpropan-1-ones with alkyl(aryl)magnesium halides. Some of the final compounds converted into dihydrochlorides. The influence on C-180 mouse tumor DNA methylation was studied in vitro incubating drug solutions (3 × 10–6 M) homogenates at 37°C (thermostatted) for 24 h. Rather ...

The structures of two salts of flunarizine, namely 1-bis[(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine, C26H26F2N2, are reported. In flunarizinium nicotinate {systematic name: 4-bis[(4-fluorophenyl)methyl]-1-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-ium pyridine-3-carboxylate}, C26H27F2N2(+)·C6H4NO2(-), (I), the two ionic components are linked by a short charge-assisted N-H.....

Levamisole (the laevorotatory isomer of tetramisole) is a new synthetic anthelmintic. A cure rate of 91% was obtained in a series of 111 ascariasis-infected children treated with a single oral dose of the drug. The failures, who were treated with the drug a second time one week later, were all cured. In a comparative study of levamisole and piperazine citrate in a series of 100 children with as...

In the title compound, C(26)H(43)N(7)O, each piperazine ring adopts a chair conformation. Two 1-methyl-piperazine rings bond to one Csp(3) of the pyrrole ring via the piperazine N atoms, while the third one links to the N atom of the indolin-2-one unit through a flexible ethyl group with an almost syn conformation. In the crystal, mol-ecules are connected through methyl-ene-carbonyl C-H⋯O inter...

Hydro-thermal reaction of NaSCN, piperazine, Zn(II) and 2,6-naphthalenedicarboxylic acid in aqueous solutions gave rise to the title complex, [Zn(NCS)(3)(C(4)H(11)N(2))]. The Zn(II) atom is four-coordinate with distorted tetra-hedral geometry and lies in a mirror plane. N-H⋯S hydrogen bonds assemble the mol-ecules to form a three-dimensional framework.

The complete mol-ecule of the title compound, C(8)H(12)N(4), is generated by a crystallographic inversion centre. The piperazine ring adopts a chair conformation with the N-bonded substituents in equatorial positions. In the crystal, mol-ecules are linked by C-H⋯N(c) (c = cyanide) hydrogen bonds.

Parkinson’s disease (PD) is a progressive neurodegenerative disorder mainly characterized by movement dysfunction. Earlier, it was found that (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol (Prottremin) demonstrated antiparkinsonian activity in vivo on different animal models of PD. The paper presents synthesis new Prottremin derivative, (1R,2R,6S)-2(4-(4-isopropylbenzyl)piperazin...

Some pentafluoropyridine derivatives have been synthesized by the reaction of pentafluoropyridine with appropriate C, S and N-nucleophile such as malononitrile, 1-methyl-tetrazole-5-thiol and piperazine. These reactions provided 4-substituted 2,3,5,6-tetrafluoropyridine derivatives in good yields. All the compounds were characterized using (1)H, (13)C and (19)F-NMR spectroscopy and X-ray crysta...