Alcohol use is prevalent during adolescence, yet little is known about possible long-lasting consequences. Recent evidence suggests that adolescents are less sensitive than adults to ethanol's aversive effects, an insensitivity that may be retained into adulthood after repeated adolescent ethanol exposure. This study assessed whether intermittent ethanol exposure during early or late adolescenc...

BACKGROUND Safe and effective therapies are needed for pediatric patients with psoriasis. OBJECTIVE The purpose of this study was to evaluate ustekinumab in patients age 12 to 17 years who had moderate-to-severe psoriasis. METHODS Patients (n = 110) were randomly assigned to ustekinumab standard dosing (SD; 0.75 mg/kg [≤60 kg], 45 mg [>60-≤100 kg], and 90 mg [>100 kg]) or half-standard dosi...

Drought stress is a major abiotic constraint limiting crop production world wide. In current study, we investigated the adverse effects of drought stress on growth, yield and endogenous phytohormones of soybean. Polyethylene glycol (PEG) solutions of elevated strength (8% & 16%) were used for drought stress induction. Drought stress period span for two weeks each at pre and post flowering growt...

increasing the water use efficiency in crop production is an important issue today. an experiment was conducted in 2009 in order to evaluate the corn reaction to partial root zone drying at fars province. treatments consisted of four irrigation levels (control, alternative furrow irrigation during whole season, alternative furrow irrigation until flowering then full irrigation and full irrigati...

A total of 135 measurements of polyfructoside clearance as a measure of glomerular filtration rate (GFR) were made in 39 infants of 25.5-33 weeks' gestation, birth weight 720-2000 g, between the ages of 0.5 and 33 days. GRF was related to postconceptional age and increased exponentially from geometric mean 0.59 ml/min at 26 weeks' postconceptional age to 1.40 ml/min at 33 weeks. GFR in the firs...

Article info: Received: 27 August 2014 Accepted: 13 November 2014 ABSTRACT Root biomass accumulation in spring and winter varieties and hybrids pea was recorded in field experiment in the Institute of Forage Crops, Pleven, Bulgaria (2011-2013). Spring (Shtambovyi and Pleven 4) and winter (Rosacrono and Pleven 10) varieties and their hybrids (Shtambovyi x Pleven 10 and Rosacrono х Pleven 4) (in ...

This study investigated the oral bioavailability and efficacy of BILS 45 BS, a selective herpes simplex virus (HSV) helicase-primase inhibitor, against acyclovir (ACV)-resistant (ACV(r)) infections mediated by the HSV type 1 (HSV-1) dlsptk and PAA(r)5 mutant strains. In vitro, the compound was more potent than ACV against wild-type clinical and laboratory HSV-1 strains and ACV(r) HSV isolates, ...

Three years into diagnosis she had symptoms of increasing tiredness, breathlessness and tachycardia. An echocardiogram confirmed ventricular dilatation suggesting myocardial involvement. She was recommenced on Cyclophosphamide with Methyprednisolone, and was also commenced on Frusemide and Enalapril which initiated control of her cardiac function. Her ejection fraction improved from 30% to 52%....

Three different ethanol solutions were sprayed onto Cabernet Sauvignon (Vitis vinifera L.) clusters during the ripening period: 2.5, 5 and 10% by volume in water. Controls were sprayed with water alone. Three different times of spraying were also tested: 8, 10 and 13 weeks post-flowering. One of the observed changes was a lower titratable acidity in grape samples at harvest, when the clusters w...

BACKGROUND Pharmacokinetics of an i.v. prodrug of acetaminophen (propacetamol) in neonates after repeat dosing are reported, with scant data for i.v. acetaminophen formulation. METHODS Neonates from an intensive care unit received 6-hourly prn i.v. acetaminophen dosed according to postmenstrual age (PMA): 28-32 weeks, 10 mg kg(-1); 32-36 weeks, 12.5 mg kg(-1); and > or =36 weeks, 15 mg kg(-1)...