Downlo atocellular carcinoma (HCC) is generally a fatal disease due to a paucity of effective treatment options. entification of oncogenic microRNAs that exert pleiotropic effects in HCC cells may offer new theratargets. In this study, we have identified the human microRNA miR-191 as a potential target for HCC y. Inhibition of miR-191 decreased cell proliferation and induced apoptosis in vitro ...

This document contains the responses to the T10 Letter Ballot comments on forwarding SAM-2 to first public review. The summary of the T10 Letter Ballot results can be found in 02-123r1. All references to SAM-2 PDF pages are based on sam2r23.pdf. r0 All comments from 02-123r1 included. Some comments noted for discussion during the May T10 meeting week. Many comments unprocessed. r1 Resolutions o...

The hypernovae (HNe) associated with Gamma-ray Bursts (GRBs) may have a fairly steep energy-velocity distribution, i.e., E(≥ β) ∝ β for q < 2 and β ≥ βo, where β is the velocity of the material and βo ∼ 0.1 is the velocity of the slowest ejecta of the HN explosion, both in units of the speed of light (c). The cosmic ray protons above the second knee but below the ankle may be accelerated by the...

In the title compound, C(19)H(15)NO(3)S, the dihydro-phenanthrene unit is not planar, its central ring being distorted towards a sofa conformation. The essentially planar thia-zole ring [maximum deviation = 0.005 (1) Å] is inclined at a dihedral angle of 85.29 (5)° with respect to the mean plane formed through the dihydro-phenanthrene unit. In the crystal structure, pairs of inter-molecular C-H...

Kinetic studies with 3,4-dihydroxy-9, IO-secoandrosta1,3,5(10)-triene-9,17-dione-4,5-dioxygenase gave intersecting initial velocity plots that conform to a sequential mechanism. Linear noncompetitive product inhibition patterns were observed with respect to either substrate, indicating the formation of a dead end complex. 4-Isopropyl catechol, a structural analogue of the organic substrate, inh...

The combined activities of rabbit liver cytosolic serine hydroxymethyltransferase and C1-tetrahydrofolate synthase convert tetrahydrofolate and formate to 5-formyltetrahydrofolate. In this reaction C1-tetrahydrofolate synthase converts tetrahydrofolate and formate to 5,10-methenyltetrahydrofolate, which is hydrolyzed to 5-formyltetrahydrofolate by a serine hydroxymethyltransferase-glycine compl...