Two families of regioisomeric 1,4-benzodiazepines, 4-benzyl-3H-benzo[e][1,4]diazepin-5-ones and 4-benzoyl-4,5-dihydro-3H-benzo[e][1,4]diazepines, have been synthesized through a similar Ugi/reduction cyclization sequence. Their conformation and stability depend on the position of the tautomeric imine/enamine equilibrium present in the diazepine nucleus, which in turn depends on the relative pos...

Many endoscopists sometimes prefer to perform endoscopies without anaesthetic support, using only benzodiazepines. Endogenous opioid peptides are believed to play an important role in the modulation of pain within the endogenous analgesic system. A group of 40 patients undergoing diagnostic and therapeutic Endoscopic Retrograde Cholangiography and Pancreatography (ERCP) was recruited. Patients ...

Jill: A handful of past studies have suggested a link between dementia and benzodiazepine use. Because it is not possible to do randomized controlled trials to evaluate this, researchers are working to answer this important public health question by accumulating evidence in many different populations and settings to assess whether the relationship is causative or merely an association with othe...

The advantages of the benzodiazpines as oral premedicants are: clear anxiolytic and sedative effect; less clear amnesic action which may prevent the recall of the time spent lying on an uncomfortable theatre trolley, but not necessarily recall of the journey to the operating theatre, or induction of anaesthesia; convenient route of administration; long duration of action of 5-8 h which simplifi...

There are now more recently published studies that also support this view and which add to the reasons I gave in my previous column as to why the presence of chronic pain and the prescription of opioids are usually contraindications for prescribing benzodiazepines. The pharmacy benefit company Express Scripts examined 6.8 million patients who filled at least one prescription for an opioid from ...

The cycloaddition reaction of diphenylnitrilimine on the 1,5-benzodiazepines has been studied. New molecules of triazolobenzodiazepines type have been isolated and characterized.

Benzodiazepines, one of the most commonly prescribed class of drugs for the pharmacological treatment of sleep disorders, are controversially discussed for their adverse effects such as physical dependence and withdrawal. Because of the effects of Benzodiazepines, feigning sleep disorders, also described as malingering, may be a viable mean for individuals to get access to prescription of benzo...

GHB is an increasingly popular drug of abuse that can be associated in select cases with growing dependence and a severe withdrawal syndrome. While benzodiazepines are recommended for treatment of the withdrawal syndrome, some cases have been described as benzodiazepine-resistant. The authors describe treatment of such a case, which was unsuccessfully treated initially with benzodiazepines, the...