نتایج جستجو برای: 5 fu
تعداد نتایج: 1219550 فیلتر نتایج به سال:
تاثیر قطره میتومایسین C و تزریق زیر ملتحمه 5- فلورواوراسیل در درمان نارسایی زودرس بلب (Failing Bleb)
هدف: مقایسه اثربخشی و ایمنی قطره چشمی میتومایسین C (MMC) و تزریق زیر ملتحمهای 5- فلورواوراسیل (5-FU) جهت درمان نارسایی زودرس بلب (Bleb) پس از جراحی ترابکولکتومی یا ترابکولکتومی و فیکوامولسیفیکاسیون، به همراه کارگذاری لنز داخل چشمی (PT+PCIOL). روش پژوهش: در مطالعهای مقایسهای، 37 چشم از 37 بیمار که مستعد به نارسایی زودرس بلب بودند، مورد بررسی قرار گرفتند. قطره چشمی MMC 02/0 درصد چهار مرت...
Recently, we have reported that tegafur, an anticancer agent, is biotransformed into active drug 5-fluorouracil (5-FU) by cytochromes P450 1A2, 2A6, and 2C8 in human liver microsomes (T. Komatsu et al., Drug Metab. Dispos, 28: 1457-1463, 2000). Because the conversion of tegafur into 5-FU has also been reported to be catalyzed by cytosolic thymidine phosphorylase (dThdPase), the involvement of h...
This is a 57-year-old right-handed male with a history of locally advanced esophageal adenocarcinoma, who presented with confusion and speech changes. Patient received 5-Fluorouracil (5-FU) and cisplatin four days prior to presentation, which was complicated by very poor oral intake on day 2 of therapy. On the day of presentation, he was confused and his speech was slurred. The remainder of the...
Patients with sporadic microsatellite instable colorectal cancers, in most of which the function of the hMLH1 mismatch repair gene is impaired, do not gain a survival benefit from 5-fluorouracil (5-FU)-based chemotherapy. However, the effect of hMLH1 on the cytotoxicity induced by 5-FU has not yet been sufficiently confirmed. In this study, we assessed the effect of hMLH1 on cytotoxicity and ap...
PURPOSE 5-Fluorouracil (5-FU) has been the mainstay treatment for colorectal cancer for the past few decades. However, as with other cancers, development of 5-FU resistance has been a major obstacle in colorectal cancer chemotherapy. The purpose of this study was to gain further understanding of the mechanisms underlying 5-FU resistance in colorectal cancer cells. EXPERIMENTAL DESIGN A 5-FU-r...
purpose: to compare the efficacy and safety of topical mitomycin-c (mmc) drops versus subconjunctival 5-fluourouracil (5-fu) injections for management of early bleb failure after trabeculectomy or combined phacoemulsification and trabeculectomy with posterior chamber intraocular lens implantation (pt+pciol). methods: in a comparative study, 37 eyes of 37 patients with impending early bleb failu...
The purpose of our study was to develop a pharmacokinetic model to quantify the intracellular 5-fluorouracil (5-FU) concentration in liver metastases, which is expected to be closely correlated to therapy response. In addition, the influence of the biomodulator folinic acid on the action of 5-FU in the metastases was investigated. After i.v. application of 5-FU labeled with the positron emitter...
OBJECTIVE We investigated the effects of hyperbaric oxygen (HBO2) and/or 5-fluorouracil (5-FU) on the proliferation and metastasis of human nasopharyngeal carcinoma (NPC) cell line CNE2Z and the underlying mechanisms involved. METHODS Nasopharyngeal carcinoma (NPC) CNE2Z cells were randomly divided into four groups: Group A: control group; Group B: 5-FU group; Group C: HBO2 group; Group D: 5-...
This study investigated the protective effects of carvedilol alone and coadministered with prednisolone and diltiazem on doxorubicin (DOX) and 5-fluorouracil (5-FU)-induced toxicity. Each of 2 pools of 70 female rats were randomly allotted into 10 groups of 7 animals each and treated as follows: Group 1: normal saline (10 mL/kg); Group 2: normal saline and DOX (40 mg/kg)/5-FU (20 mg/kg) alone; ...
The objective of this study was to prepare cubosomal nanoparticles containing a hydrophilic anticancer drug 5-fluorouracil (5-FU) for liver targeting. Cubosomal dispersions were prepared by disrupting a cubic gel phase of monoolein and water in the presence of Poloxamer 407 as a stabilizer. Cubosomes loaded with 5-FU were characterized in vitro and in vivo. In vitro, 5-FU-loaded cubosomes entra...
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