Optimization of long term immunity depends on the functional persistence of memory T cells; however, there are no defined strategies for promoting memory T cell function and survival. In this study, we hypothesized that varying the strength of the recall stimulus could modulate the function and survival potential of memory CD4 T cells. We tested the ability of peptide variants of influenza hema...

Influenza epidemics occur annually, and estimated 5-10% of the adult population and 20-30% of children will become ill from influenza infection. Seasonal vaccines primarily work through the induction of neutralizing antibodies against the principal surface antigen hemagglutinin (HA). This important role of HA-specific antibodies explains why previous pandemics have emerged when new HAs have app...

Some effects of l&m endophyte (Acremonium lolioe) on sheep production were evaluated using pure swards of h igh (SO%>) and low (< 5%) endophyte Nui and Ar ik i ryegrass. The proportion of infected t i l lers in high endophyte treatments increased by 19% in 15 months. Ryegrass staggers occurred on both high endophyte ryegrasses being sl ight ly worse on Nui . The peak ryegrass staggers outbreak ...

Unprimed T cells transferred to heavily irradiated H-2-compatible mice cause a high incidence of lethal graft-vs.-host disease (GVHD)a in certain strain combinations (1-3). GVHD in this setting is a consequence of mature post-thymic donor T cells responding to the multiple minor histocompatibility antigen (minor HA) differences of the host. With the combination of CBA and B10.BR (both H-2~), do...

The flavor changing top quark decays t → cV (V = Z, γ, g) induced by R-parity-violating couplings in the minimal supersymmetric standard model (MSSM) are evaluated. We find that the decays t → cV can be significantly enhanced relative to those in the R-parity conserving SUSY model. Our results show that the top quark FCNC decay can be as large as Br(t → cg) ∼ 10−3, Br(t → cZ) ∼ 10−4 and Br(t → ...

Results of a previous study suggested that recipient mismatching for the minor histocompatibility antigen HA-1 is associated with acute graft-versus-host disease (GVHD) after allogeneic marrow transplantation. In that study, most patients received either cyclosporine or methotrexate for GVHD prophylaxis, and a cytotoxic T-cell clone was used to test for HA-1 disparity. To facilitate large-scale...

Nonobese diabetic (NOD) mice develop spontaneous autoimmune diabetes that involves participation of both CD4+ and CD8+ T cells. Previous studies have demonstrated spontaneous reactivity to self-Ags within the CD4+ T cell compartment in this strain. Whether CD8+ T cells in NOD mice achieve and maintain tolerance to self-Ags has not previously been evaluated. To investigate this issue, we have as...

Ž . Ž . Inputs of either napier grass NG or diammonium phosphate plus urea NP containing similar Ž y1 y1. Ž y1 y1. amounts of nitrogen 17 kg N ha week and phosphorus 1.2 kg P ha week were made to Tilapia rendalli ponds from which offspring were either partially removed or left to grow. After Ž . 364 days, average weight of stocked fish in NG ponds 74.3 g was significantly higher Ž . Ž . P-0.05 ...

The aim of this study was to analyze the behavior of the porous nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite grafted for bone defect repair through a series of biological safety experiments, animal experiments, and a more than 5-year long clinical follow-up. The biological safety experiments, carried out in accordance with the Chinese Guo Biao and Tolerancing (GB/T)16886 and GB/T16175...

as compared to ksc 704 hybrid with 9.844 t/ha, the maize hybrid, ksc 705(k3640/3 × mo17) produced an average grain yield of 11.120 t/ha over seven locations evaluated in final trials for two consecutive years (2007-8). in advanced yield trials done in 2011, across seven locations, this hybrid performed the highest grain yield, 10.450 t/ha, while ksc 704 produced 8.513 t/ha. in addition to the g...