Intravenous mineralocorticoid receptor antagonists (MRAs) have been used in some centers for decades to reduce the risk of hypokalemia and boost diuresis acutely decompensated heart failure (ADHF). We report well-tolerated use intravenous MRAs as a rescue procedure 3 patients admitted ADHF with important diuretic resistance. Undertaking trials evaluating effect this therapeutic strategy could r...

Recently, we could show that gonadotropin-releasing hormone (GnRH)-II antagonists induce apoptosis in human endometrial, ovarian, and breast cancer cells in vitro and in vivo. In the present study, we have ascertained receptor binding and effects of GnRH-II antagonists on mitogenic signal transduction and on activation of proapoptotic protein Bax. The GnRH-II antagonists tested showed EC50 valu...

This study examined the pharmacological identity of the tachykinin receptors which in the rat stomach mediate vasoconstriction and muscular contraction. The vasculature of the rat isolated stomach was perfused with oxygenated Krebs buffer containing 3% dextran. Vasoconstrictor responses were recorded as increases in the vascular perfusion pressure and gastric contractions were measured as incre...

Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology poorly understood, it known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1) channel play significant role in induced by rodents. However, of signalling pathways downstream from B2 activation sensitisation TRPA1 remains unknown...

1. Abstract The discovery of the CART transcript and peptides implicated peptide (CARTp) as a neurotransmitter involved in action psychostimulants several other physiological processes, buttressing importance CARTp system. While there is evidence that receptor(s) for exists, has/have not been cloned. To understand how functions, it important to identify its receptor(s). Given receptor GPCR, rea...

BACKGROUND It is unknown whether proton pump inhibitors are superior to H2-receptor antagonists in Helicobacter pylori eradication regimens. AIM To perform a meta-analysis comparing the efficacy of both antisecretors when co-prescribed with antibiotics. METHODS Randomized clinical trials comparing proton pump inhibitors vs. H2-receptor antagonists with the same antibiotics were selected. Da...

The study was carried out to desensitize spontaneously active isolated chick rectum with salbutamol in log doses starting from 100 nanogram and resensitize with various drugs as a result to revive the desensitized tissue and respond to Salbutamol. The tissue response after desensitization to alpha, beta adrenergic and muscarinic acetylcholine receptor antagonists was isotonically recorded for 1...

Transcutaneous electrical nerve stimulation (TENS) is an analgesia inducing method with increasing applications in clinical procedures. In this study we tried to evaluate the role of the adrenergic system and its different adrenoceptor subtypes in TENS-induced analgesia. Two types of low and high frequency electrical stimuli were used in rats through needle electrodes, inserted at the base ...