H an s B o ck 3*, W olfgang Seitz3, N o rb e rt N agel3, R ü d ig er B a u rb, Jan W. B a ts3, Z d e n e k H av la sc, R odney F. C. C laridged a Chemische Institute der Universität Frankfurt, Marie-Curie-Str. 11, D-60439 Frankfurt am Main b Hoechst AG, Postfach 800320, D-65926 Frankfurt/Main c Institut für Organische Chemie und Biochemie, Tschechische Akademie der Wissenschaften, Flemingova Na...

Chan-Lam cross coupling allowed efficient synthesis of N,N'-disubstituted ortho-phenylene diamines bearing strong electron donating or withdrawing groups, such as nitro or methoxy groups, with moderate to high yields. These diamines can then be turned into N-heterocyclic carbene precursors after condensation with trimethyl orthoformate. The same strategy can also be utilized for the synthesis o...

The fused 2-vinyl or 2-phenyl substituted cyclobutanones 4 undergo stereoselective ring openings by the action of alkoxide ions (t-BuO(-) or MeO(-)) to produce novel vicinally disubstituted cycloalkene derivatives 5 and 6 in moderate to high yields. The ring cleavage usually occurs with complete regioselectivity. The accessibility of γ,δ-unsaturated ester or acid derivatives makes this transfor...

An effective and eco friendly procedure under microwave irradiation, for synthesis of symmetrical disubstituted alkyl and aryl ureas from amine hydrochlorides using water as solvent medium has been developed. Based on molecular docking studies on HIV-1 gp120, synthesized compounds were evaluated for HIV-1 gp120 – CD4 binding inhibition and these molecules showed micro molar range (0.047 μM to 4...

Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduced RmtF protein had 25 to 46% identity with members of the N7 G1405 family of ...

The mol-ecule of the title compound, C(18)H(17)N(3), with the exception of the -C(CH(3))(2) group, is nearly planar [maximum deviation: 0.208 (4), r.m.s. deviation 0.099 (6) Å] and the disubstituted C atom is displaced by 0.679 (2) Å from the mean plane through the remaining non-H atoms. In the crystal, the packing is stabilized by weak C-H⋯π inter-actions.