Immune checkpoint blockade (ICB) therapy has brought hope to many cancer patients, but the response rate is low in types, and acquired resistance ICB can develop over time. Oncolytic viruses are promising therapeutic agents for advanced cancers. Modified vaccinia virus Ankara (MVA) an attenuated, replication-deficient poxvirus safe human use, making it a favorable platform immunotherapy. Our fi...

Background Malignant pleural mesothelioma (MPM) is a rare and aggressive inflammatory cancer commonly associated with prior exposure to asbestos. Until recently, approved systemic treatments for MPM have been limited chemotherapy regimens that had survival benefit overall poor outcomes. Both immune checkpoint inhibitors (ICIs) tumor treating fields (TTF) improved in this population. As result o...

Mikhail Gorman, Amir Lahav, Elliot Saltzman, and Margrit Betke *Image and Video Computing Group Department of Computer Science Boston University 111 Cummington Street Boston, MA 02215 USA {mishaz,betke}@cs.bu.edu †Music Mind & Motion Laboratory Sargent College for Health and Rehabilitation Science Boston University 635 Commonwealth Avenue Boston, MA 02215 USA [email protected] **The Music & Neuroim...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313 5.6 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 356 6.4 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 391 7.0 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 357 6.4 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

A young boy presented with monoparesis of the left arm. MRI disclosed bilateral enhancing thalamic lesions. Biopsy results and subsequent clinical history were most compatible with postinfectious or acute disseminated encephalomyelitis. This represents one of the first cases of acute disseminated encephalomyelitis affecting the thalami, established by biopsy. This uncommon disease entity is rev...