Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to acti...

as celesticetin2) (2) have been prepared3) by synthetic anc microbiological transformation, involving modificatior of the parent antibiotics both at the sugar moiety anc the amino acid side-chain (Fig. 1). Of these new derivatives 7(S)-chloro-7-deoxylincomycin4) (3, cleocin, clindamycin) is one of the most important, possessing mon pronounced and wider spectrum of antibiotic activity, a* well a...

The title compound, [Ru(C(10)H(15))Cl(C(12)H(10)ClP)(C(17)H(20)NP)], is a half-sandwich complex of Ru(II) with the chloro-diphenyl-phosphine ligand formed from the diphenyl-piperidinophosphine and chlorine of the precursor complex [Ru(η(5)-C(5)Me(5))(κ(1)P-Ph(2)PNC(5)H(10))Cl(2)] by an unexpected reaction with NaBH(4). The complex has a three-legged piano-stool geometry, with Ru-P bond lengths ...

7. Hancock BW, Naysmith A. Hypersensitivity to chlorocresolpreserved heparin. BMJ. 1975;27:746--7. 8. Freitas JP, Brandão FM. Contact urticaria to chlorocresol. Contact Dermatitis. 1986;15:252. 9. Yamano T, Shimizu M, Noda T. Allergenicity evaluation of p-chloro-m-cresol and p-chloro-m-xylenol by non-radioactive murine local lymph-node assay and multipledose guinea pig maximization test. Toxico...

The title compound, C(10)H(13)Cl(5), is a polychlorinated monoterpene and a Toxaphene congener. This compound is also the only penta-chlorinated derivative of camphene formed via ionic chlorination. Previously, the title compound was thought to be 2-exo,5-endo,9,9,10-penta-chloro-bornane, but X-ray structural analysis showed it to have a different structure and rather to be 2-exo,5-endo,8,8,10-...

To synthesize 4-chloro-5-methoxy-2-(b-trifluoroethyl)-3(2H)-pyridazinone (4), the reactions of 4-chloro-5-methoxy-3(2H)-pyridazinone (5) with RCH(2)CF(3)(R = I, TsO, MsO, TfO) in different solvents were studied. It was found that methyl group migration took place during this reaction. An oxonium salt 9 was suggested as the active intermediate for the formation of the byproduct 4-chloro-5-methox...