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Stimulation of the interleukin-6 (IL-6) signalling pathway occurs via the IL-6 receptor-glycoprotein 130 (IL-6R-gp130) receptor complex and results in the regulation of acute-phase protein genes in liver cells. Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases (Jak), phosphorylation of the signal transducing subunit gp130, followed by recru...
BACKGROUND The Magpie Trial, a randomised trial comparing magnesium sulphate with placebo for women with pre-eclampsia. This paper describes methods used for follow up in the UK, and presents additional data collected. METHODS In the UK 774 women and their 827 children were included; excluded were women discharged without a surviving child and families who opted out. General practitioners wer...
BACKGROUND AND OBJECTIVE ABO blood types are determined by antigen modifications on glycoproteins and glycolipids and associated with altered plasma levels of inflammatory and endothelial injury markers implicated in AKI pathogenesis. We sought to determine the association of ABO blood types with AKI risk in critically ill patients with trauma or sepsis. DESIGN, SETTING, PARTICIPANTS, & MEASU...
The possibility of additional quarks and leptons beyond the three generations already established is discussed. The make-up of this Report is (I) Introduction: the motivations for believing that the present litany of elementary fermions is not complete; (II) Quantum Numbers: possible assignments for additional fermions; (III) Masses and Mixing Angles: mass limits from precision electroweak data...
We examine the linear-quadratic (LQ) approximation of non-linear stochastic dynamic optimization problems in macroeconomics, in particular for monetary policy. We make four main contributions: first, we draw attention to a general Hamiltonian framework for LQ approximation due to Magill (1977). We show that the procedure for the ‘large distortions’ case of Benigno and Woodford (2003, 2005) is e...
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