Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans. Melatonin (MT) has been shown to be potentially effective in preventing oxidative stress related neurodegenerative disorders. In this study, whether MT exerted a protective effect against ACR-induced oxidative damage was investigated. Results in cells showed that reactive oxygen species (ROS) and malondialdehyde (...

Many semiarid and arid soils are prone to irrigation-induced erosion. Polyacrylamide (PAM) greatly reduces erosion from furrow irrigation. We hypothesized that PAM applied via sprinklers will provide erosion control and benefit water infiltration and aggregate stability. Screened (6.4 mm) Rad silt loam (coarse silty, mixed, superactive mesic Durinodic Xeric Haplocambid) was placed in 1.5 by 1.2...

In June 2013, the first human infection by avian influenza A(H6N1) virus was reported in Taiwan. This incident raised the concern for possible human epidemics and pandemics from H6 viruses. In this study, we performed structural and functional investigation on the hemagglutinin (HA) proteins of the human-infecting A/Taiwan/2/2013(H6N1) (TW H6) virus and an avian A/chicken/Guangdong/S1311/2010(H...

The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation against hemagglutinin domains in plasma of young and elderly individuals. AID...

Influenza virus type B strains were unexpectedly detected and isolated in Italy during summer-fall 2008 from three patients travelling to Italy from Lebanon, Senegal and Uzbekistan. The three summer-fall strains matched to a high degree the hemagglutinin (HA1) of influenza virus type B strains circulating in Italy in the second part (January through April) of the 2007/2008 season, and HA1 of th...

Copper-loading induces metallothionein (MT) synthesis in the liver of rats. Copper-MT from the liver of copper-injected rats has been isolated and analyzed. The copper-induced MT synthesis is characterized by increased incorporation of [ 35S]cysteine into the protein and enhanced production of the MT mRNA, suggesting that copper induction of MT occurs at the level of gene transcription. The mec...

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We have previously demonstrated that the globular head of the hemagglutinin (HA) antigen fused to flagellin of Salmonella typhimurium fljB (STF2, a TLR5 ligand) elicits protective immunity to H1N1 and H5N1 lethal influenza infections in mice (Song et al., 2008, PLoS ONE 3, e2257; Song et al., 2009, Vaccine 27, 5875-5888). These fusion proteins can be efficiently and economically manufactured in...

Introduction: Effects of melatonin (MT) were comparatively examined on melanophores of isolated skin in adults and tadpole’s tailfin of a frog Rana cyanophlyctis. MT is generally considered as a potent melanophores aggregating hormone besides regulating the sleep wake cycle in vertebrates. Methods: Melanophore size index (MSI) was chosen as a recording parameter of the responses. Concentr...

Among 117 of the albino mice used in this study, 108 were intraperitionally infected with 100 X 106 promastigotes of Leishmania donovani (MHOM\ IQ\ 982\ BRCI) strain, while the rest groups (9) were left without infection. The inoculation of albino mice caused the elevation of liver and spleen weight after 7-15 days and the treated mice with 20 mg/kg by Pentostam and Allupurinol for 10 and 15 da...