Background & aim: Fatigue is one of the most common complaints among pregnant women. Reflexology can be used to reduce the symptoms of fatigue.The purpose of this study was to measure the impact of foot sole reflexology on the intensity of fatigue in the first half of pregnancy. Methods: This randomized clinical...

While randomized clinical trials (RCTs) should provide the basis for evidence-based medicine, as currently designed and analyzed, they often mislead clinical decision-making. Comparative effectiveness evaluation of two treatments [Treatment 1 (T1) versus Treatment 2 (T2)] should not be determined by the statistical effect of treatments on individual measures of outcome (benefits and/or harms), ...

BACKGROUND Recent evidence has highlighted deficiencies in clinical trial protocols, having implications for many groups. Existing guidelines for randomized clinical trial (RCT) protocol content vary substantially and most do not describe systematic methodology for their development. As one of three prespecified steps for the systematic development of a guideline for trial protocol content, the...

Loss of the chromosomal region 8p21 negatively effects survival in patients with multiple myeloma (MM) that undergo autologous stem cell transplantation (ASCT). In this study, we aimed to identify the immunological and molecular consequences of del(8)(p21) with regards to treatment response and bortezomib resistance. In patients receiving bortezomib as a single first line agent without any high...

background: to compare the efficacy of two routes of prostaglandin e 2 administration (intravenous and intramuscular) for treatment of missed abortion this study was conducted. regarding the pilot cases of missed abortion admitted for termination of pregnancy intravenous administration of pge2 that had higher efficacy compare to intramuscular route, investigators designed this study. methods: i...

Whether garcinol, the active component of Garcinia indica, can modulate the sensitivity of cancer cells to TRAIL, a cytokine currently in phase II clinical trial, was investigated. We found that garcinol potentiated TRAIL-induced apoptosis of cancer cells as indicated by intracellular esterase activity, DNA strand breaks, accumulation of the membrane phospholipid phosphatidylserine, mitochondri...

TRAIL is known to play a pivotal role in the inhibition of autoimmune disease. We previously demonstrated that administration of dendritic cells engineered to express TRAIL and myelin-oligodendrocyte glycoprotein reduced the severity of experimental autoimmune encephalomyelitis and suggested that CD4(+)CD25(+) regulatory T cells (Tregs) were involved in mediating this preventive effect. In the ...

Using quantitative RT-PCR, we compared mRNA levels for TRAIL [tumor necrosis factor (TNF)-related apoptosis-inducing ligand] and its receptors in various immune cell subsets derived from the peripheral blood of untreated normal subjects (NS) and patients with distinct subtypes of multiple sclerosis (MS): active relapsing-remitting MS (RRA), quiescent relapsing-remitting MS (RRQ), secondary-prog...

Objective: To determine the effectiveness of Transcranial Direct Current Stimulation (tDCS) in contrast with video game on executive function in children with Attention Deficit Hyperactivity Children (ADHD). Methodology: This study was an unblinded Randomized Control Trial with ADHD participants recruited from various schools of Patiala District in Punjab, India.  Participants were screened fo...