Y-700 (1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid) is a newly synthesized inhibitor of xanthine oxidoreductase (XOR). Steady-state kinetics with the bovine milk enzyme indicated a mixed type inhibition with K(i) and K(i) ' values of 0.6 and 3.2 nM, respectively. Titration experiments showed that Y-700 bound tightly both to the active sulfo-form and to the inactive d...

Let X be the Dynkin diagram of a symmetrizable Kac-Moody algebra, and X0 a subgraph with all vertices of degree 1 or 2. Using the crystal structure on the components of quiver varieties for X , we show that if we expand X by extending X0, the branching multiplicities and tensor product multiplicities stabilize, provided the weights involved satisfy a condition which we call “depth” and are supp...

Moody’s KMV method is a popular commercial implementation of the structural credit risk model pioneered by Merton (1974). It is an algorithm for estimating the unobserved asset value and the unknown parameters required for implementing such a model. This estimation method has found its way to the recent academic literature, but it has not yet been formally analyzed to assess its statistical pro...

Compactification can control chaotic Mixmaster behavior in gravitational systems with p–form matter: we consider this in light of the connection between supergravity models and Kac–Moody algebras. We show that different compactifications define “mutations” of the algebras associated with the noncompact theories. We list the algebras obtained in this way, and find novel examples of wall systems ...

The current standards for meeting drug information (DI) requirements in American Society of Health-System Pharmacists (ASHP)-accredited pharmacy practice residency (PPR) programs and the impact of changes in ASHP standards for the DI requirements were studied. In September 2002 a nine-question survey was e-mailed to the directors of all ASHP-accredited PPR programs listed with an available e-ma...

We study the “fermionic billiards”, i.e. the chaotic dynamics of the gravitino, that arise in the near-spacelike-singularity limit of elevendimensional supergravity and of its dimensional truncations (notably fourdimensional simple supergravity). By exploiting the gravity-coset correspondence, we show that the billiard dynamics of the gravitino is described by a ‘spin extension’ of the E10 Weyl...

Drug information (DI) services is an essential resource for pharmacists to provide counseling to patients and guide appropriate medication use. We devised a DI practical training course that incorporated an inquiry-based practical training program and evaluated its effectiveness. A total of 91 fifth-year students in Pharmaceutical Sciences at Fukuoka University took part in the following DI ses...

Background. To estimate repeatability and comparability of central corneal thickness (CCT) and keratometry measurements obtained by four different devices in healthy eyes. Methods. Fifty-five healthy eyes from 55 volunteers were enrolled in this study. CCT (IOLMaster 700, Pentacam HR, and Cirrus HD-OCT) and keratometry readings (IOLMaster 700, Pentacam HR, and iDesign) were measured. For statis...