Up to one third of the children with epilepsy are classified as having cryptogenic localization epilepsy (CLRE). Unfortunately, not much is known on the prognosis of CLRE; it is assumed to be somewhere between the benign course of many idiopathic epilepsies and the more malignant course of most symptomatic epilepsies. The risk of cognitive decline over time seems to be increased for children wi...

Dietary therapies are established as beneficial for symptomatic generalized epilepsies such as Lennox-Gastaut syndrome; however, the outcome for idiopathic generalized epilepsy has never been specifically reported. The efficacy of the ketogenic and modified Atkins diet for childhood and juvenile absence epilepsy was evaluated from both historical literature review and patients treated at Johns ...

PURPOSE To investigate the electroclinical features and the outcome of patients with typical absences starting before the 3 years of life. METHODS We reviewed the clinical data of patients with absences started before 3 years observed over a 15-year period. Mutation analysis of SLC2A1 (GLUT-1) gene was performed when possible. Their clinical features were compared with those of subjects with ...

The mechanism by which ethosuximide reduces thalamic low-threshold calcium current (LTCC) was analyzed using voltage-clamp techniques in acutely isolated ventrobasal complex neurons from rats and guinea pigs. The ethosuximide-induced reduction of LTCC was voltage dependent: it was most pronounced at more-hyperpolarized potentials and did not affect the time course of activation or inactivation ...

OBJECTIVE Although sickness absence often is a process over time, most studies have treated the phenomenon as a discrete event and focused more on its causes than its consequences. We aimed to examine whether various patterns of previous long-term sickness absence were associated with current low perceived social support at work. METHOD This is a historical cohort study based on data from a p...

PURPOSE The aim of the study is to identify work-related determinants of return to work (RTW) of employees who are on long-term sickness absence. METHOD The study was based on a sample of 926 employees on sickness absence (maximum duration of 12 weeks). The employees filled out a baseline questionnaire and were subsequently followed until the 10th month after listing sick. Cox proportional ha...

This study examined a theoretical model that linked leadership, positive and negative workgroup environments, positive and negative affect and workgroup size with group-level voluntary and involuntary absence. Structural equation analyses were conducted on data obtained from 27,327 staff members in 852 schools. Overall, the results demonstrated that voluntary and involuntary absence each had di...

Annual sickness absence rates in Great Britain since 1950 have been compared with similar measurements obtained from eight other countries. Frequency has tended to rise more than severity, indicating a shortening of the average length of a spell. The rise in British rates is not unique, and has been exceeded in Sweden, Holland, Italy, and West Germany. From the Swedish experience with self-cert...

BACKGROUND Workplace stressors, such as bullying, are strongly related to subsequent long-term sickness absence, but little is known of the possible physiological mechanisms linking workplace stressors and sickness absence. The primary aim of this study was to investigate to what extent cortisol levels were associated with subsequent sickness absence and if cortisol mediated the association bet...

Records of sickness for all industrial employees of H.M. Dockyard, Singapore were analysed over a calendar year, 1955-56, with a view to producing a standard rate for sickness absence in the three main ethnic divisions of this area, with particular reference to age. Other factors, such as form or grade of employment and residence, were considered in order to test their effect, if any, upon sick...