BACKGROUND Adriamycin (ADR) is an anticancer drug known to cause severe cardiac toxicity by generating free radicals. We investigated the role of a redox-regulating molecule, thioredoxin-1 (TRX1), in ADR-induced cardiotoxicity. METHODS AND RESULTS The in vitro study showed that TRX1 was dose-dependently increased concomitant with the formation of hydroxyl radicals in ADR-treated neonatal rat ...

anthropogenic alterations have affected urban hydrology in india and have generated a wide range of hydrological problems. such alterations include increase in directly-connected impervious cover thus reducing natural groundwater recharge. in the past urban runoff was largely viewed as a nuisance, but within the new paradigm of sustainability, this water is recognized as a potential resource. t...

Karst aquifer studies often focus on allogenic water inputs and large conduit flow. However, diffuse recharge can be significant, particularly in unconfined eogenetic karst aquifers that retain high matrix permeability. This study examines an unconfined region of the upper Floridan aquifer (USA) that hosts a sinking stream, its resurgence, and a large conduit system. Daily diffuse recharge was ...

abstract the coupled modflow-hydrus software package was used to produce a saturated-unsaturated flow model for a flood spreading system (fss) and its associated aquifer. the study aim to improve simulations of near-surface hydrological processes, including temporal and spatial variation in groundwater recharge rates. the coupled model was built with average rmse=1.1 and 1.3 for calibration and...

Scientific domain: %scientific_domain Subject short description: Water shortage and decline of the quality of fresh water resources make sea water desalination become a major way for drinking water production. Reverse Osmosis (RO) is now the main technology used for seawater desalination, but it shows a limited recovery and the environmental impact of large volumes of rejected brines is still a...

Humans have exerted large-scale changes on the terrestrial biosphere, primarily through agriculture; however, the impacts of such changes on the hydrologic cycle are poorly understood. The purpose of this study was to test the hypothesis that the conversion of natural rangeland ecosystems to agricultural ecosystems impacts the subsurface portion of the hydrologic cycle by changing groundwater r...

artificial recharge can be an effective method to raise the groundwater table and to resolve the groundwater crisis in sefid dasht plain. the most important step to successful accomplishment of artificial recharge is locating suitable areas for artificial recharge. hence this research carried out with purpose of determining suitable areas for artificial recharge in sefid dasht plain. slope, sur...

[1] Decision making in water resources management usually requires the quantification of uncertainties. Monte Carlo techniques are suited for this analysis but imply a huge computational effort. An alternative and computationally efficient approach is the first-order second-moment (FOSM) method which directly propagates parameter uncertainty into the result. We apply the FOSM method to both the...

PURPOSE Although the combination of Adriamycin (ADR) and docetaxel (DOC) showed a better cure rate against metastatic breast cancer in a clinical study, severe myelosuppression and cardiotoxicity were dose-limiting factors. The purpose of this study was to establish the most suitable dosing schedule to relieve severe adverse effects and improve the antitumor effects. EXPERIMENTAL DESIGN Both ...

Adriamycin (ADR) is a chemotherapeutic for the treatment of solid tumors. This quinone-containing anthracycline is well known to produce large amounts of reactive oxygen species (ROS) in vivo. A common complaint of patients undergoing long-term treatment with ADR is somnolence, often referred to as "chemobrain." While ADR itself does not cross the blood brain barrier (BBB), we recently showed t...