نتایج جستجو برای: acetylcholinesterase inhibition
تعداد نتایج: 334136 فیلتر نتایج به سال:
The plant Cardaria draba (L.) Desv. subsp. (Brassicaceae), is traditionally used for various ailments in different cultures. We investigated solvent extracts such as methanol, ethanol, and water obtained from flowers, leaves, stems, roots of C. their chemical composition, well antioxidant enzyme inhibition activities acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ?-glucosidase, ?-am...
Rivastigmine, a carbamate inhibitor of acetylcholinesterase, is already in use for treatment of Alzheimer's disease under the trade name of Exelon. Rivastigmine carbamylates Torpedo californica acetylcholinesterase very slowly (k(i) = 2.0 M(-1) min(-1)), whereas the bimolecular rate constant for inhibition of human acetylcholinesterase is >1600-fold higher (k(i) = 3300 M(-1) min(-1)). For human...
Acetylcholinesterase (AChE; EC 3.1.1.7) is a group of enzymes that catalyzes the hydrolysis neurotransmitter acetylcholine (ACh) into choline and acetate. AChE inhibition commonly utilized as biomarker for pesticides. In membrane based biosensors enzyme immobilization onto an electrode surface prime importance. previous studies, conducting polymers-based supports have been used AChE. this study...
In this work, previously synthesized tetra-chalcone-substituted metallophthalocyanines (MPcs) containing Ni(II), Zn(II), Co(II), and Cu(II) in the inner core were investigated anticholinergic activities against Alzheimer's disease (AD). The MPcs evaluated for their inhibition of acetylcholinesterase (AChE) butyrylcholinesterase (BChE) using original Ellman's colorimetric procedure. Against thes...
Objective(s): To investigate the efficiency of a novel series of coumarin derivatives bearing benzoheterocycle moiety as novel cholinesterase inhibitors. Materials and Methods: Different 7-hydroxycoumarin derivatives were synthesized via Pechmann or Knoevenagel condensation and conjugated to different benzoheterocycle (8-hydroxyquinoline, 2-mercaptobenzoxazole or 2-mercaptobenzimidazole) using ...
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