Since the topic of the role of the kidneys in the regulation of acid-base balance was last reviewed from a teaching perspective (Koeppen BM. Renal regulation of acid-base balance. Adv Physiol Educ 20: 132-141, 1998), our understanding of the specific membrane transporters involved in H(+), HCO(3)(-), and NH(4)(+) transport, and especially how these transporters are regulated in response to syst...

Background: Volume overload and fluid congestion remain primary clinical challenges in the assessment and management of patients with chronic heart failure (HF). Summary: The pathophysiology of volume regulation is complex, and the simple concept of passive intravascular fluid accumulation is not adequate. The dynamics of interstitial and intravascular fluid compartment interactions and fluid r...

Acid-base homeostasis and pH regulation are critical for both normal physiology and cell metabolism and function. The importance of this regulation is evidenced by a variety of physiologic derangements that occur when plasma pH is either high or low. The kidneys have the predominant role in regulating the systemic bicarbonate concentration and hence, the metabolic component of acid-base balance...

Maintenance of acid-base homeostasis is a vital function of the living organism. Deviations of systemic acidity in either direction can impose adverse consequences and when severe can threaten life itself. Acid-base disorders frequently are encountered in the outpatient and especially in the inpatient setting. Effective management of acid-base disturbances, commonly a challenging task, rests wi...

BACKGROUND Intensivists spend much of their time managing problems related to fluids, electrolytes, and blood pH. Recent advances in the understanding of acid-base physiology have resulted from the application of basic physical-chemical principles of aqueous solutions to blood plasma. All changes in blood pH, in health and in disease, occur through changes in three variables: carbon dioxide, re...

From the standpoint of processing, hard chromium layer plate may be applied to steels, cast iron, aluminum and nickel base alloys. Cast iron can be plated provided that the surface is capable of conducting the required current and is reasonably free of voids, pits, gross silicate inclusions, and massive segregation. There are many difficulties arising from graphite phase and deposition of hydro...

High-sucrose diet and metabolic acidosis have some similar effects on bone and they both reduce the formation of dentine. This series of experiments was conducted in order to get information about the effects of acidosis and alkalosis on dentine during primary dentinogenesis and also to ascertain if high-sucrose diet affects dentine formation via acidosis. Chronic metabolic acidosis (0.25 mol/L...

After studying this chapter you should be able to: b Define the normal range for plasma pH. c Explain the role of the kidney in the steady state elimination of acid produced daily by metabolism. d Outline the defence mechanisms which act to prevent an abrupt change in pH in response to an acid load. e Describe the mechanism for acid transport in the different nephron segments. f Recognize the c...

aintaining acid base balance presents a considerable challenge to the growing neonate. The infant ust ingest protein for growth and development. The metabolism of sulfur containing amino acids eads to the production of protons that must be secreted by the kidney. In addition, the formation of ydroxyapatite for the mineralization of growing bone also leads to acid production. Thus, the rowing in...