1. The formation in vivo of retinoic acid from microgram quantities of intrajugularly administered [15-(14)C]retinol was demonstrated in the rat. 2. Endogenously formed retinoic acid (about 0.1mug./rat) was found in liver, and to a much smaller extent in intestine, 12hr. after retinol administration. 3. Excretion of some of the endogenously formed retinoic acid occurred in the bile of bile-duct...

Mohanram, M., and Kumar, A. (1975). Archives of Disease in Childhood, 50, 235. Ascorbic acid and tyrosine metabolism in preterm and small-fordates infants. Ascorbic acid levels in plasma and leucocytes and urinary excretion of tyrosyl derivatives (TD) were determined in 11 normal, 18 preterm, and 4 smallfor-dates infants. Concentrations of ascorbic acid in both plasma and leucocytes were found ...

The relationship between urinary excretion of porphyrins, porphyrin precursors and total oestrogens in normal pregnancy was investigated. Significant increases in total oestrogen, delta-aminolaevulinic acid (ALA) and coproporphyrin (COPRO) excretion were noted. However, no close correlation was found between total oestrogen excretion and urinary output of ALA and COPRO. The results suggest that...

On a 'normal' diet increased faecal bile acid excretion was found in 14 of 16 children with cystic fibrosis who had steatorrhoea, but excretion was normal in 2 such children without steatorrhoea. The 16 children with steatorrhoea took 3 regimens of diet and therapy: a 'normal' diet with pancreatic enzyme supplements, a diet of reduced long-chain triglycerides with added mediumchain triglyceride...

5/3,7a-Dihydroxy-11-ketotetranor-prostanoic acid was the major metabolite excreted in the urine of guinea pigs injected with tritium-labeled prostaglandin E1, prostaglandin EP, 110~ ,15~-dihydroxy-9-ketoprost-5-enoic acid, lla-hydroxy-9,15-diketoprostanoic acid, and 11~hydroxy-9,15diketoprost-5-enoic acid. A method was developed for quantitative determination of 5p ,‘7cr-dihydroxy-l l -ketotetr...

I , [z4-14C]cholic acid was given to conventional and germ-free rats and the faecal isotope excretion studied for 8 days. The turnover, pool size and daily excretion of cholic acid and its rnctabolites were calculated for rats on three different diets, i.e. a commercial type diet (pellets), a semi-synthetic diet without (D7) and with 20% cellulose (D7+cellulose). The transit time of theintestin...

Magnesium and calcium deficiency in humans is related to a number of pathological phenomena such as arrhythmia, osteoporosis, migraine, and fatal myocardial infarction. Clinically established metabolic acidosis induces renal losses of calcium. In normal subjects, even moderate increases in net endogenous acid production (NEAP) impair renal calcium reabsorption but no information is available wh...

It has been shown by Krehl et aZ.l that tryptophane may replace nicotinic acid as a growth factor for rats receiving a corn diet. Rosen et al2 have demonstrated that the administration of tryptophane to rats increases the excretion of nicotinic acid derivatives. Experiments reported here with human subjects show that the administration of tryptophane leads to an increased excretion of N1-methyl...

Rainbow trout were infused continuously for 24 h with epinephrine in order to elevate circulating levels to those measured during periods of acute extracellular acidosis (about 5 X 10(-8) mol l-1). Concomitant effects on branchial solute fluxes were evaluated. Epinephrine infusion caused complex and differential adjustments of Na+ and Cl- unidirectional fluxes (influx and efflux) resulting in a...

Caterpillars of Manduca sexta use two distinct transport mechanisms for the excretion of dyes. One pump (Type A) has a high affinity for acid (anionic) dyes and occurs in the midgut and medial Malpighian tubules. Acid dyes accumulate rapidly in the lumen of the midgut while the Malpighian tubules appear to play only a minor role in the excretion of these dyes. The other pump (Type B) excretes b...