BACKGROUND Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. OBJECTIVE The purpose of this study is to demonstrate the biological behavior of melanoma subty...

Primary cutaneous melanomas are usually divided into three separate clinicopathologic groups: lentigo maligna melanoma (LMM), superficial spreading melanoma. (SSM), and nodular melanoma (NM). Acral lentiginous melanoma has been described as the fourth distinct subtype to denote those melanomas that arise on volar and subungual skin. This entity is said to have a radial growth phase histological...

PURPOSE Gain-of-function mutations in BRAF, NRAS, or KIT are associated with distinct melanoma subtypes with KIT mutations and/or copy number changes frequently observed among melanomas arising from sun-protected sites, such as acral skin (palms, soles, and nail bed) and mucous membranes. GAB2 has recently been implicated in melanoma pathogenesis, and increased copy numbers are found in a subse...

Zinc-responsive acral dermatitis is a rare entity characterized by chronic, persistent, well-defined, hyperpigmented, and hyperkeratotic plaques on the regions of body. One needs to differentiate this disease from its close differentials such as necrolytic migratory erythema pellagra. Herein, we report case zinc-responsive dermatosis in 35-year-old female previously treated with multiple topica...