نتایج جستجو برای: acting antiviral
تعداد نتایج: 108524 فیلتر نتایج به سال:
Ledipasvir (LDV; GS-5885), a component of Harvoni (a fixed-dose combination of LDV with sofosbuvir [SOF]), is approved to treat chronic hepatitis C virus (HCV) infection. Here, we report key preclinical antiviral properties of LDV, including in vitro potency, in vitro resistance profile, and activity in combination with other anti-HCV agents. LDV has picomolar antiviral activity against genotyp...
The prevalence of hepatitis C virus (HCV) infection amongst patients with chronic kidney disease (CKD) and end-stage renal disease exceeds that of the general population. In addition to predisposing to the development of cirrhosis and hepatocellular carcinoma, infection with HCV has been associated with extra-hepatic complications including CKD, proteinuria, glomerulonephritis, cryoglobulinemia...
Liver biopsy is historically the gold standard for liver fibrosis assessment of chronic hepatitis C patients. However, with introduction and validation noninvasive tests (NITs) to evaluate advanced fibrosis, direct-acting antiviral agents treatment virus (HCV), role NITs have become even more complex. There now need longitudinal monitoring elucidation cutoff values prediction liver-related comp...
an alternative in vitro approach to drug screening has been the use of human cell cultures for antiviral agents and microbial cell cultures for the assessment of the carcinogenic potential of selected compounds. a number of protozoan species have been also used as drug screens for anti-protozoal agents. the ciliated protozoan tetrahymena pyriformis species has been widely utilised as a drug scr...
To develop antiviral therapeutics against human coronavirus (HCoV) infections, suitable drug targets and corresponding lead molecules must be urgently identified. Here, we describe the discovery of a class HCoV inhibitors acting on nsp15, hexameric protein component viral replication-transcription complexes, endowed with immune evasion-associated endoribonuclease activity. Structure–activity re...
Reactivation of Herpesvirus in Patients With Hepatitis C Treated With Direct-Acting Antiviral Agents
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