A critical unanswered question about mixed lineage leukemia (MLL) is how specific MLL fusion partners control leukemia phenotype. The MLL-cyclic AMP-responsive element binding protein-binding protein (CBP) fusion requires both the CBP bromodomain and histone acetyltransferase (HAT) domain for transformation and causes acute myelogenous leukemia (AML), often preceded by a myelodysplastic phase. ...

The chromatin remodeling activity of the Swi/Snf complex is essential for the expression of several yeast genes. Previous studies have suggested that recruitment of Swi/Snf requires the action of transcriptional activators. However, reports in metazoans and in yeast have provided evidence of interactions between Swi/Snf and the RNA polymerase II holoenzyme/Mediator complex. Here we show that re...

FastOpt’s new automatic differentiation tool TAF is applied to the two-dimensional Navier-Stokes solver NSC2KE. For a configuration that simulates the Euler flow around a NACA airfoil, TAF has generated the tangent linear and adjoint models as well as the second derivative (Hessian) code. Owing to TAF’s capability of generating efficient adjoints of iterative solvers, the derivative code has a ...

Mitotic repression of rRNA synthesis requires inactivation of the RNA polymerase I (Pol I)-specific transcription factor SL1 by Cdk1/cyclin B-dependent phosphorylation of TAF(I)110 (TBP-associated factor 110) at a single threonine residue (T852). Upon exit from mitosis, T852 is dephosphorylated by Cdc14B, which is sequestered in nucleoli during interphase and is activated upon release from nucl...

a r t i c l e i n f o a b s t r a c t Digital watermarking techniques have been proposed for copyright protection and au-thentication of multimedia data. In this paper, we propose a novel Chinese Remainder Theorem (CRT)-based technique for digital watermarking in the Discrete Cosine Transform (DCT) domain that is robust to several common attacks. We compared the performance of the proposed tech...

LIM-homeodomain 3 (LHX3) is a transcription factor required for mammalian pituitary gland and nervous system development. Human patients and animal models with LHX3 gene mutations present with severe pediatric syndromes that feature hormone deficiencies and symptoms associated with nervous system dysfunction. The carboxyl terminus of the LHX3 protein is required for pituitary gene regulation, b...

packet reservation multiple access (TAF-PRMA) protocol, which optimizes random access control between heterogeneous traffic aiming at more efficient voice/data integrated services in dynamic reservation TDMA-based broadband access networks. In order to achieve a differentiated quality-of-service (QoS) guarantee for individual service plus maximal system resource utilization, TAF-PRMA independen...

Approximately 84% of human immunodeficiency virus (HIV)-infected US residents on antiretroviral therapy currently receive some form of tenofovir disoproxil fumarate (TDF) as part of their HIV treatment regimen. The TDF analogue tenofovir alafenamide (TAF) has demonstrated equal efficacy but with decreased renal injury and bone mineral density loss compared with TDF. We examine how much more soc...

Contents Currently, there is great interest in the use case technique and the Unified Modeling Language (UML). This paper explains how use cases and UML models are somewhat limited in the information they provide to testers. Any effective set of tests represents a detailed understanding of the requirements of the unit under test, as well as the interfaces provided to the test drivers. Although ...

Posterior cervical foraminotomy is an effective surgical technique for the treatment of radicular pain caused by foraminal stenosis or posterolateral herniated discs. The present study was performed to compare the clinical parameters and surgical outcomes of open foraminotomy/discectomy (OF/OFD) and tubular retractor assisted foraminotomy/discectomy (TAF/TAFD) in the treatment of cervical radic...