Our previous studies have shown that Fc gamma receptor (FcgammaR)-mediated uptake of LDL-containing immune complexes (oxLDL-ICs) by human monocyte-derived macrophages leads to not only transformation of macrophages into foam cells but also macrophage activation and release of cytokines. It has been shown that cross-linking of FcgammaR triggers activation of signal transduction pathways that alt...

Hemodynamic abnormalities are important in the pathogenesis of the excess mesangial matrix deposition of diabetic and other glomerulopathies. p38-Mitogen-activated protein (MAP) kinase, an important intracellular signaling molecule, is activated in the glomeruli of diabetic rats. We studied, in human mesangial cells, the effect of stretch on p38 MAP kinase activation and the role of p38 MAP kin...

Models of spatial attention are often based on the concept of a salience map. In computational cognitive neuroscience, such maps are implemented as a collection of nodes with self-excitation and lateral inhibition between all nodes (competitive interaction map). Here, we test some critical predictions of this idea. We argued that task demands, more precisely the level of attention required, can...

The black-box nature of deep neural networks severely hinders its performance improvement and application in specific scenes. In recent years, class activation mapping-based method has been widely used to interpret the internal decisions models computer vision tasks. However, when this uses backpropagation obtain gradients, it will cause noise saliency map even locate features that are irreleva...

OBJECTIVE To investigate the potential mechanisms of cell death after the treatment with ceramide. METHODS MTT assay, DNA ladder, reporter assay, FACS and Western blot assay were employed to investigate the potential mechanisms of cell death after the treatment with C2-ceramide. RESULTS A short-time treatment with C2-ceramide induced cell death, which was associated with p38 MAP kinase acti...

BACKGROUND Many infants who undergo heart surgery have a congenital cyanotic defect in which the heart is chronically perfused with hypoxic blood. However, the signaling pathways by which infant hearts adapt to chronic hypoxia and resist subsequent surgical ischemia is unknown. METHODS AND RESULTS We determined the activation and translocation of protein kinase C (PKC) isoforms and mitogen ac...